Ischemic stroke events impose a substantial burden on both families and society, underscoring the critical importance of early intervention and prevention strategies. The dearth of familial and societal support significantly impacts coping styles and family resilience, with negative coping styles potentially linked to diminished levels of family resilience. However, empirical evidence supporting these associations remains lacking.The aim of this study was to examine the association between simplified coping style, perceived social support and family resilience in patients with ischemic stroke, while also investigating the potential mediating role of simplified coping style in the relationship between perceived social support and family resilience.Convenience sampling was employed to select patients with ischemic stroke from three tertiary hospitals in Hunan Province between May and November 2021. A comprehensive investigation was conducted using a General data questionnaire, Simplified Coping Style Questionnaire, Perceived Social Support Scale and Family Resilience Rating Scale. The mediating effect was analyzed using PROCESS macros in SPSS, while the significance was tested through the Bootstrap method.A total of 310 questionnaires were distributed, with 7 identified as containing errors, omissions, or losses. Of these, 303 valid questionnaires were collected, yielding an effective response rate of 97.74 %. The scores for family resilience among ischemic stroke patients showed significant positive correlations with simple coping style (r = 0.59, P < 0.01) and perceived social support (r = 0.69, P < 0.01). Additionally, there was a positive correlation between perceived social support and simple coping style (r = 0.56, P < 0.01). Furthermore, the simple coping style played a crucial mediating role in the relationship between perceived social support and family resilience by accounting for approximately 20.70 % of the effect size.The findings suggest that enhancing positive coping styles and effective social support can enhance the level of family resilience in patients with ischemic stroke. Therefore, medical professionals should focus on improving social support while targeting coping styles as an intervention strategy to actively adjust the coping modes, ultimately elevating the level of family resilience in patients with ischemic stroke.Copyright © 2024 Elsevier Inc. All rights reserved.