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Exploring the frontiers: The potential and challenges of bioactive scaffolds in osteosarcoma treatment and bone regeneration

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机构： [1]Department of Orthopedics, Jinshan Hospital, Fudan University, Shanghai, 201508, China. [2]Changhai Clinical Research Unit, Shanghai Changhai Hospital, Naval Medical University, Shanghai, 200433, China. [3]Department of Cardiovascular Surgery, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China. [4]Digestive Endoscopy Center, Shanghai Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200336, China. [5]Department of Orthopedics, Huashan Hospital, Fudan University Shanghai, 201508, China. [6]Shanghai Key Laboratory of Nautical Medicine and Translation of Drugs and Medical Devices, Shanghai, 200336, China.

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关键词： Surgery Chemotherapy Osteosarcoma Bone regeneration Integrated bioactive scaffolds

摘要：

The standard treatment for osteosarcoma combines surgery with chemotherapy, yet it is fraught with challenges such as postoperative tumor recurrence and chemotherapy-induced side effects. Additionally, bone defects after surgery often surpass the body's regenerative ability, affecting patient recovery. Bioengineering offers a novel approach through the use of bioactive scaffolds crafted from metals, ceramics, and hydrogels for bone defect repair. However, these scaffolds are typically devoid of antitumor properties, necessitating the integration of therapeutic agents. The development of a multifunctional therapeutic platform incorporating chemotherapeutic drugs, photothermal agents (PTAs), photosensitizers (PIs), sound sensitizers (SSs), magnetic thermotherapeutic agents (MTAs), and naturally occurring antitumor compounds addresses this limitation. This platform is engineered to target osteosarcoma cells while also facilitating bone tissue repair and regeneration. This review synthesizes recent advancements in integrated bioactive scaffolds (IBSs), underscoring their dual role in combating osteosarcoma and enhancing bone regeneration. We also examine the current limitations of IBSs and propose future research trajectories to overcome these hurdles.© 2024 The Authors.

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出版当年[2023]版：

大类 | 1 区医学

小类 | 2 区工程：生物医学 2 区材料科学：生物材料

最新[2023]版：

大类 | 1 区医学

小类 | 2 区工程：生物医学 2 区材料科学：生物材料

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出版当年[2022]版：

Q1 ENGINEERING, BIOMEDICAL Q1 MATERIALS SCIENCE, BIOMATERIALS

最新[2023]版：

Q1 ENGINEERING, BIOMEDICAL Q1 MATERIALS SCIENCE, BIOMATERIALS

影响因子： 8.7 最新[2023版] 8.8 最新五年平均 8.2 出版当年[2022版] 9 出版当年五年平均 10.761 出版前一年[2021版] 8.7 出版后一年[2023版]

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第一作者机构： [1]Department of Orthopedics, Jinshan Hospital, Fudan University, Shanghai, 201508, China.

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通讯机构： [2]Changhai Clinical Research Unit, Shanghai Changhai Hospital, Naval Medical University, Shanghai, 200433, China. [6]Shanghai Key Laboratory of Nautical Medicine and Translation of Drugs and Medical Devices, Shanghai, 200336, China.

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