Aging is characterized by a progressive loss of physiological integrity, leading to impaired function and increased vulnerability to death. Aging is an important risk factor for eye diseases. The gradual deterioration of ocular tissue structure and function with age leads to the onset and progression of ocular diseases. During aging, ocular tissues such as the lens, vitreous and retina are affected by age-related changes, such as oxidative stress and protein accumulation in the lens leading to cataract formation, and a decline in retinal pigment epithelial cell function associated with macular degeneration. This article reviews the relationships between aging and ocular diseases, takes age-related macular degeneration, age-related cataracts, glaucoma, diabetic retinal degeneration, and dry eye disease as focal points, analyses the complex interactions between aging and ocular diseases, and describes the therapeutic options and potential targets for age-related ocular diseases.
基金:
The work was supported by the 2021 Chengdu Fourth
Batch of Technology Innovation R&D Project (2021-
YF05-0064-9SN).
第一作者机构:[1]Chengdu Univ Tradit Chinese Med, Sch Med & Life Sci, Chengdu, Peoples R China
通讯作者:
通讯机构:[1]Chengdu Univ Tradit Chinese Med, Sch Med & Life Sci, Chengdu, Peoples R China[2]Southeast Univ, Nanjing Tongren Hosp, Hlth Management Ctr, Sch Med, Nanjing, Peoples R China[4]Chengdu Xinhua Hosp, North Sichuan Med Coll, Sci Educ Dept, Chengdu, Peoples R China[5]Chengdu First Peoples Hosp, Dept Ophthalmol, Chengdu, Peoples R China[*1]Naniing Tongren Hospital, School of Medicine, Southeast University,Nanjing, China[*2]School of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, China[*3]Chengdu First People's Hospital, Chengdu, China[*4]Chengdu Xinhua Hospital Affiliated to North Sichuan Medical College, Chengdu, China
推荐引用方式(GB/T 7714):
You Luling,Lin Yumeng,Zheng Yizhuo,et al.The Impact of Aging on Ocular Diseases: Unveiling Complex Interactions[J].AGING AND DISEASE.2025,doi:10.14336/AD.2024.0850.
APA:
You, Luling,Lin, Yumeng,Zheng, Yizhuo,Han, Zhongyu,Zeng, Liuzhi&Chen, Haoran.(2025).The Impact of Aging on Ocular Diseases: Unveiling Complex Interactions.AGING AND DISEASE,,
MLA:
You, Luling,et al."The Impact of Aging on Ocular Diseases: Unveiling Complex Interactions".AGING AND DISEASE .(2025)