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Mechanisms of autophagy and their implications in dermatological disorders

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机构: [1]Chengdu Univ Tradit Chinese Med, Sch Med & Life Sci, Affiliated Hosp, Deyang Hosp, Deyang, Peoples R China [2]Southeast Univ, Nanjing Tongren Hosp, Hlth Management Ctr, Sch Med, Nanjing, Peoples R China [3]North Sichuan Med Coll, Chengdu Xinhua Hosp, Chengdu, Peoples R China
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关键词: autophagy psoriasis systemic lupus erythematosus vitiligo atopic dermatitis pemphigus systemic sclerosis

摘要:
Autophagy is a highly conserved cellular self-digestive process that underlies the maintenance of cellular homeostasis. Autophagy is classified into three types: macrophage, chaperone-mediated autophagy (CMA) and microphagy, which maintain cellular homeostasis through different mechanisms. Altered autophagy regulation affects the progression of various skin diseases, including psoriasis (PA), systemic lupus erythematosus (SLE), vitiligo, atopic dermatitis (AD), alopecia areata (AA) and systemic sclerosis (SSc). In this review, we review the existing literature focusing on three mechanisms of autophagy, namely macrophage, chaperone-mediated autophagy and microphagy, as well as the roles of autophagy in the above six dermatological disorders in order to aid in further studies in the future.

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出版当年[2023]版:
大类 | 2 区 医学
小类 | 2 区 免疫学
最新[2025]版:
大类 | 2 区 医学
小类 | 2 区 免疫学
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Q1 IMMUNOLOGY
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Q1 IMMUNOLOGY

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第一作者机构: [1]Chengdu Univ Tradit Chinese Med, Sch Med & Life Sci, Affiliated Hosp, Deyang Hosp, Deyang, Peoples R China
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