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Inflammatory Myofibroblastic Tumor of the Orbit: A Case Series and Literature Review

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机构: [1]Capital Med Univ, Beijing Friendship Hosp, Dept Ophthalmol, Beijing 100050, Peoples R China [2]Beijing Ophthalmol & Visual Sci Key Lab, Beijing 100730, Peoples R China [3]Beijing Fengtai Youanmen Hosp, Beijing, Peoples R China [4]Capital Med Univ, Beijing TongRen Hosp, Dept Pathol, Beijing 100730, Peoples R China [5]Capital Med Univ, Beijing Tongren Hosp, Dept Radiol, Beijing 100730, Peoples R China [6]Univ Western Australia, Ctr Ophthalmol & Visual Sci, Perth, WA, Australia [7]Univ Melbourne, Dept Surg, Ophthalmol, Melbourne, Vic, Australia [8]Royal Perth Hosp, Dept Ophthalmol, Perth, WA, Australia
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关键词: inflammatory myofibroblastic tumor orbit MRI pathologic prognosis

摘要:
Purpose: Orbital inflammatory myofibroblastic tumors (IMTs) are a rare tumor with intermediate biological potential. We analyzed a series of orbital IMTs to determine their unique features. Methods: Records from patients with pathologically confirmed IMT at Beijing Tongren Hospital, Capital Medical University, between January 2004 and August 2022, were reviewed for their ocular presentation and treatment outcomes. Results: Thirteen cases of primary orbital IMT with positive anaplastic lymphoma kinase on fluorescent in situ hybridization were included. These consists of five men and eight women with an age of onset ranged from 2 to 54 years. Nearly half of the primary orbital IMTs displayed local invasion into the maxillary sinus, ethmoid sinus, and pterygopalatine fossa. On magnetic resonance imaging, orbital IMT usually appeared as an ill-defined, oval, irregular, or diffuse mass with heterogeneous signals. Nearly half (46.2%) of these lesions caused bone destruction, and 31% developed recurrence, which was more likely to occur in lesions involving multiple tissues (50%). All cases of recurrence occurred within five months after the first surgery. No patient developed distant metastases. Conclusion: Orbital IMT is rare and prone to local invasion and recurrence. The histology and behavior of orbital IMT requires further investigation.

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出版当年[2023]版:
大类 | 2 区 医学
小类 | 3 区 免疫学
最新[2025]版:
大类 | 3 区 医学
小类 | 3 区 免疫学
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出版当年[2022]版:
Q2 IMMUNOLOGY
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Q2 IMMUNOLOGY

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第一作者机构: [1]Capital Med Univ, Beijing Friendship Hosp, Dept Ophthalmol, Beijing 100050, Peoples R China [2]Beijing Ophthalmol & Visual Sci Key Lab, Beijing 100730, Peoples R China
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通讯机构: [2]Beijing Ophthalmol & Visual Sci Key Lab, Beijing 100730, Peoples R China [*1]Capital Med Univ, Beijing Tongren Hosp, Beijing Tongren Eye Ctr, Beijing 100730, Peoples R China
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