Purpose: Orbital inflammatory myofibroblastic tumors (IMTs) are a rare tumor with intermediate biological potential. We analyzed a series of orbital IMTs to determine their unique features. Methods: Records from patients with pathologically confirmed IMT at Beijing Tongren Hospital, Capital Medical University, between January 2004 and August 2022, were reviewed for their ocular presentation and treatment outcomes. Results: Thirteen cases of primary orbital IMT with positive anaplastic lymphoma kinase on fluorescent in situ hybridization were included. These consists of five men and eight women with an age of onset ranged from 2 to 54 years. Nearly half of the primary orbital IMTs displayed local invasion into the maxillary sinus, ethmoid sinus, and pterygopalatine fossa. On magnetic resonance imaging, orbital IMT usually appeared as an ill-defined, oval, irregular, or diffuse mass with heterogeneous signals. Nearly half (46.2%) of these lesions caused bone destruction, and 31% developed recurrence, which was more likely to occur in lesions involving multiple tissues (50%). All cases of recurrence occurred within five months after the first surgery. No patient developed distant metastases. Conclusion: Orbital IMT is rare and prone to local invasion and recurrence. The histology and behavior of orbital IMT requires further investigation.
基金:
Capital Health Research and Development of Special Fund [2020-2-1082]; Natural Science Foundation of Beijing Municipality [7222028]
第一作者机构:[1]Capital Med Univ, Beijing Friendship Hosp, Dept Ophthalmol, Beijing 100050, Peoples R China[2]Beijing Ophthalmol & Visual Sci Key Lab, Beijing 100730, Peoples R China
通讯作者:
通讯机构:[2]Beijing Ophthalmol & Visual Sci Key Lab, Beijing 100730, Peoples R China[*1]Capital Med Univ, Beijing Tongren Hosp, Beijing Tongren Eye Ctr, Beijing 100730, Peoples R China
推荐引用方式(GB/T 7714):
Guo Sitong,Wang Songze,Chen Chunli,et al.Inflammatory Myofibroblastic Tumor of the Orbit: A Case Series and Literature Review[J].JOURNAL OF INFLAMMATION RESEARCH.2024,17:11029-11039.doi:10.2147/JIR.S485499.
APA:
Guo, Sitong,Wang, Songze,Chen, Chunli,He, Xiaojin,Yang, Bentao...&Chen, Fred Kuanfu.(2024).Inflammatory Myofibroblastic Tumor of the Orbit: A Case Series and Literature Review.JOURNAL OF INFLAMMATION RESEARCH,17,
MLA:
Guo, Sitong,et al."Inflammatory Myofibroblastic Tumor of the Orbit: A Case Series and Literature Review".JOURNAL OF INFLAMMATION RESEARCH 17.(2024):11029-11039