机构：[1]Department of Otolaryngology-Head and Neck Surgery, Shanghai Key Laboratory of Sleep Disordered Breathing, Otolaryngology Institute of Shanghai Jiao Tong University, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.[2]Clinical Research Center, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.[3]Department of Otorhinolaryngology and National Health Commission (NHC) Key Laboratory of Otorhinolaryngology, Shandong University Affiliated Qilu Hospital, Jinan, China.[4]Department of Otolaryngology-Head and Neck Surgery, First Affiliated Hospital of Nanchang University, Jiangxi, China.[5]Department of Otolaryngology Head and Neck Surgery, Huashan Hospital, Fudan University, Shanghai, China.[6]Department of Otolaryngology, Head and Neck Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.[7]Nursing Department of Otolaryngology Head and Neck Surgery & Center of Sleep Medicine, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.[8]Department of Radiology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.[9]Department of Clinical Laboratory, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.[10]Department of Gerontology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.[11]Department of Epidemiology, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China.[12]Hongqiao International Institute of Medicine, Shanghai Tong Ren Hospital and Clinical Research Institute, Shanghai Jiao Tong University School of Medicine, Shanghai, China.[13]Department of Otorhinolaryngology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.[14]Department of Otorhinolaryngology-Head and Neck Surgery, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.[15]Department of Otorhinolaryngology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine Shanghai, China.[16]Hongqiao International Institute of Medicine, Shanghai Tongren Hospital and School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China.[17]Departments of Psychiatry, Neurology and Epidemiology, University of California, San Francisco, CA, USA.[18]Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, CA, USA.
Obstructive sleep apnea (OSA) is associated with cognitive impairment. The effects of continuous positive airway pressure (CPAP) on neuroimaging biomarkers and cognitive performance among middle-aged patients with OSA and normal cognition remain unclear.To investigate the effects of CPAP therapy over 12 months on neuroimaging biomarkers and cognitive performance.In this multicenter, randomized clinical trial, we randomly assigned 148 participants with normal cognition and an apnea-hypopnea index ≥15/hour into two groups: patients receiving CPAP with best supportive care (BSC); and patients receiving BSC alone. The primary endpoint was MoCA score at 6 months after enrollment. The secondary endpoints were intranetwork functional connectivity (FC) of default mode network (DMN) and cortical thickness assessed by functional and structural magnetic resonance imaging, other neuroimaging biomarkers and neurobehavioral tests.Between 2017 and 2021, 148 patients were recruited from 5 hospitals. Linear mixed models showed that there was no significant difference in MoCA scores at 6 months between the CPAP and BSC groups (difference, -0.04, 95% confidence interval (CI), -0.72 to 0.65, P=0.91). However, there were significant differences in the FC of DMN (difference, -13.73, 95% CI, -23.40 to -4.06, P=0.01) and cortical thickness (difference, -0.06 mm, 95% CI, -0.10 to -0.01mm, P=0.02) between CPAP and BSC groups at 6 months after treatment. No serious adverse events occurred.CPAP improved cortical thickness and FC of DMN, suggesting that patients with OSA may recover from brain atrophic processes following CPAP treatment. However, no improvement in MoCA was found. Clinical trial registration available at www.gov, ID: NCT02886156.
基金：
STI2030-Major Projects (2021ZD0201900) from National Key R&D Program of China;Interdisciplinary Program of Shanghai Jiao Tong University (YG2023LC11); a grant
(DLY201502) from multi-center clinical research project from school of medicine, Shanghai
Jiao Tong University; a grant (18DZ2260200) from Shanghai Municipal Commission of
Science and Technology; a grant (2017-01-07-00-02-E00047) from Innovation Program of
Shanghai Municipal Education Commission; National Natural Science Foundation of China
(82341242, 82101205); Medical Engineering Cross Research Fund of Shanghai Jiao Tong
University (YG2024QNA36).
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2025]版：
大类|1 区医学
小类|1 区危重病医学1 区呼吸系统
最新[2025]版：
大类|1 区医学
小类|1 区危重病医学1 区呼吸系统
第一作者：
第一作者机构：[1]Department of Otolaryngology-Head and Neck Surgery, Shanghai Key Laboratory of Sleep Disordered Breathing, Otolaryngology Institute of Shanghai Jiao Tong University, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Xu Huajun,Liu Yupu,Li Chenyang,et al.Effects of CPAP on Neuroimaging Biomarkers and Cognition in Adult OSA: A Randomized Controlled Trial[J].American Journal Of Respiratory And Critical Care Medicine.2025,doi:10.1164/rccm.202406-1170OC.
APA：
Xu Huajun,Liu Yupu,Li Chenyang,Li Xinyi,Shen Li...&Yin Shankai.(2025).Effects of CPAP on Neuroimaging Biomarkers and Cognition in Adult OSA: A Randomized Controlled Trial.American Journal Of Respiratory And Critical Care Medicine,,
MLA：
Xu Huajun,et al."Effects of CPAP on Neuroimaging Biomarkers and Cognition in Adult OSA: A Randomized Controlled Trial".American Journal Of Respiratory And Critical Care Medicine .(2025)
医学