Objectives: Human papillomavirus (HPV) infection is closely related to upper respiratory mucosal lesions, and the most common disease is adult upper respiratory papilloma, which has a certain probability of cancer transformation.This study conducted in vitro tissue and cell experiments to explore the inflammatory mechanisms associated with HPV + adult laryngeal papilloma. Methods: We compared differential expression of AIM2 and IL-1 beta between HPV (High-risk) negative and positive adult laryngeal papilloma patients. In vitro experiments were conducted to investigate the differences in expression of AIM2, Caspase-1, and IL-1 beta in HPV- and HPV+ upper respiratory mucosal cells. Results: The expression level of AIM2 and IL-1 beta was higher in HPV (High-risk) positive papilloma tissue than HPV (High-risk) negative papilloma tissue. The expression of AIM2, Caspase-1, and IL-1 beta in HPV+ cells was also significantly higher than in HPV- cells. Conclusions: The expression of IL-1 beta mediated by AIM2 was associated with chronic inflammation of upper respiratory mucosal tissue caused by HPV infection, and it may yet be associated with further pathological changes.
基金：
National Natural Science Foundation
of China (Grant Nos. 82071032 and 82072997). Beijing Hospitals Authority Clinical medicine Development of special funding support, code: ZLRK202304.
第一作者机构：[1]Capital Med Univ, Beijing Tongren Hosp, 1 Dongjiaomin Lane, Beijing 100730, Peoples R China
推荐引用方式(GB/T 7714)：
Yin Gaofei,Chen Xiaohong,Zhang Yang,et al.Exploration of the role of AIM2/IL-1β in adult laryngeal papilloma[J].SCIENCE PROGRESS.2025,108(1):doi:10.1177/00368504241292457.
APA：
Yin, Gaofei,Chen, Xiaohong,Zhang, Yang,Huang, Zhigang&Guo, Wei.(2025).Exploration of the role of AIM2/IL-1β in adult laryngeal papilloma.SCIENCE PROGRESS,108,(1)
MLA：
Yin, Gaofei,et al."Exploration of the role of AIM2/IL-1β in adult laryngeal papilloma".SCIENCE PROGRESS 108..1(2025)
