机构：[1]Department of Allergy, Beijing TongRen Hospital, Capital Medical University, Beijing, China.临床科室变态反应科首都医科大学附属北京同仁医院首都医科大学附属同仁医院[2]Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China.临床科室耳鼻咽喉-头颈外科首都医科大学附属北京同仁医院首都医科大学附属同仁医院[3]Beijing Institute of Otolaryngology, Beijing Laboratory of Allergic Diseases, Beijing Key Laboratory of Nasal Diseases, Key Laboratory of Otolaryngology Head and Neck Surgery, Ministry of Education, Capital Medical University, Beijing, China.研究所耳鼻咽喉科研究所首都医科大学附属北京同仁医院首都医科大学附属同仁医院[4]Research Unit of Diagnosis and Treatment of Chronic Nasal Diseases, Chinese Academy of Medical Sciences, Beijing, China.
Vascular endothelial growth factors (VEGFs) play a crucial role in regulating physiological angiogenesis and homeostasis during growth and development. Recent advancements in our knowledge of VEGFs have revealed their complex role in coordinating vascular homeostasis and pathological role in various airway allergic reactions and structural remodeling, especially in allergic asthma and allergic rhinitis (AR), which has become more apparent.After an extensive search of PubMed and Web of Science databases, our review covered articles published from 1989 to 2024. The purpose of this review was to review previous studies on VEGFs involved in inflammatory progression and tissue remodeling in airway allergic diseases, to summarize the relevant pathways. This article further reviews that VEGFs and their receptors can also be potential targets for treating airway allergic diseases.The prevalence of airway allergic diseases is increasing, which has caused a serious economic burden. VEGFs and their receptors have been recognized as potential targets for therapeutic interventions, which have been effectively applied in the treatment of tumors and other diseases. Fully elucidating the involvement of VEGFs in the disease process will help us understand their mechanisms of action and develop targeted therapies for allergic diseases.
第一作者机构：[1]Department of Allergy, Beijing TongRen Hospital, Capital Medical University, Beijing, China.[2]Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China.[3]Beijing Institute of Otolaryngology, Beijing Laboratory of Allergic Diseases, Beijing Key Laboratory of Nasal Diseases, Key Laboratory of Otolaryngology Head and Neck Surgery, Ministry of Education, Capital Medical University, Beijing, China.[4]Research Unit of Diagnosis and Treatment of Chronic Nasal Diseases, Chinese Academy of Medical Sciences, Beijing, China.
共同第一作者：
通讯作者：
通讯机构：[1]Department of Allergy, Beijing TongRen Hospital, Capital Medical University, Beijing, China.[2]Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China.[3]Beijing Institute of Otolaryngology, Beijing Laboratory of Allergic Diseases, Beijing Key Laboratory of Nasal Diseases, Key Laboratory of Otolaryngology Head and Neck Surgery, Ministry of Education, Capital Medical University, Beijing, China.[4]Research Unit of Diagnosis and Treatment of Chronic Nasal Diseases, Chinese Academy of Medical Sciences, Beijing, China.
推荐引用方式(GB/T 7714)：
Zhang Yu,Li Jingyun,Zhang Luo,et al.Vascular endothelial growth factors in airway allergic diseases: pathophysiological functions and therapeutic prospects[J].Expert Review Of Clinical Immunology.2025,21(5):577-586.doi:10.1080/1744666X.2025.2499597.
APA：
Zhang Yu,Li Jingyun,Zhang Luo&Zhang Yuan.(2025).Vascular endothelial growth factors in airway allergic diseases: pathophysiological functions and therapeutic prospects.Expert Review Of Clinical Immunology,21,(5)
MLA：
Zhang Yu,et al."Vascular endothelial growth factors in airway allergic diseases: pathophysiological functions and therapeutic prospects".Expert Review Of Clinical Immunology 21..5(2025):577-586
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