机构：[1]Upper Airways Research Laboratory, ENT Department, Ghent University, Gent, Belgium[2]Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China首都医科大学附属北京同仁医院临床科室耳鼻咽喉-头颈外科[3]Division of ENT Diseases, Clintec, Karolinska Institute, Stockholm, Sweden
Allergic airway diseases are typically characterized by a type 2-biased inflammation. Multiple distinct viruses and bacteria have been detected in the airways. Recently, it has been confirmed that the microbiome of allergic individuals differs from that of healthy subjects, showing a close relationship with the type 2 response in allergic airway disease. In this review, we summarize the recent findings on the prevalence of viruses and bacteria in type 2-biased airway diseases and on the mechanisms employed by viruses and bacteria in propagating type 2 responses. The understanding of the microbial composition and postinfectious immune programming is critical for the reconstruction of the normal microflora and immune status in allergic airway diseases.
基金：
European CommissionEuropean CommissionEuropean Commission Joint Research Centre [260895]; Flemish Scientific Research Board, FWOFWO [1841713N, G.039412N, G.067512N, BOF14/GOA/019]; Interuniversity Attraction Poles Program-Belgian State Belgian Science PolicyBelgian Federal Science Policy Office [IAP P7/30]
第一作者机构：[1]Upper Airways Research Laboratory, ENT Department, Ghent University, Gent, Belgium[2]Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China
通讯作者：
通讯机构：[1]Upper Airways Research Laboratory, ENT Department, Ghent University, Gent, Belgium[3]Division of ENT Diseases, Clintec, Karolinska Institute, Stockholm, Sweden[*1]Upper Airway Research Laboratory, Department of OtoRhino-Laryngology, Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
推荐引用方式(GB/T 7714)：
Lan F.,Zhang N.,Gevaert E.,et al.Viruses and bacteria in Th2-biased allergic airway disease[J].ALLERGY.2016,71(10):1381-1392.doi:10.1111/all.12934.
APA：
Lan, F.,Zhang, N.,Gevaert, E.,Zhang, L.&Bachert, C..(2016).Viruses and bacteria in Th2-biased allergic airway disease.ALLERGY,71,(10)
MLA：
Lan, F.,et al."Viruses and bacteria in Th2-biased allergic airway disease".ALLERGY 71..10(2016):1381-1392
医学