机构：[1]Department of Otolaryngology–Head and Neck Surgery, Beijing Tongren Hospital and Key Laboratory of Otolaryngology–Head and Neck Surgery, Capital Medical University, Ministry of Education, Beijing, China首都医科大学附属北京同仁医院
Objectives/Hypothesis: To investigate the role of airway patency and factors associated with airway patency in patients with chronic rhinosinusitis with nasal polyps (CRSwNP) and asthma. Study Design: Retrospective study. Methods: The upper and lower airway patency of 140 patients with CRSwNP and asthma (asthma group) and 42 patients with CRSwNP without asthma (nonasthma control group) was measured using acoustic rhinometry, rhinomanometry, and spirometry. Total serum immunoglobulin E and eosinophil counts were also compared. The severity of nasal diseases in these patients was assessed via the LundMackay score (LMS) and LundKennedy score (LKS). Results: There was no difference between the asthma and nonasthma groups in terms of total nasal resistance at 75 Pa (R75T), bilateral minimum cross-sectional area (MCAR+L), or bilateral nasal cavity volume between 0 and 7.0 cm3 (V7R+L). Forced expiratory volume in 1 second (FEV1) and forced expiratory flow between 25% and 75% of forced vital capacity (FEF2575) of the asthma group were significantly lower than those of the nonasthma group. FEV1 and FEF2575 were not correlated with R75T, MCAR+L, V7R+L, or severity of nasal disease. For the patients with asthma, LMS and serum eosinophil counts were independent predictors of MCAR+L. Conclusions: The presence of asthma may not influence upper airway patency in CRSwNP patients. In CRSwNP patients with asthma, impairment of upper airway patency was associated with changes in LMS and eosinophilia, and in these patients lower airway patency was significantly lower than that of the control group (without asthma). In CRSwNP patients with asthma, there was little or no association between upper and lower airway patency. Laryngoscope, 2013
基金：
Beijing Municipal Health Bureau [2009-3-36]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [30973283]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2012]版：
大类|4 区医学
小类|2 区耳鼻喉科学4 区医学：研究与实验
最新[2023]版：
大类|3 区医学
小类|2 区耳鼻喉科学3 区医学：研究与实验
JCR分区：
出版当年[2011]版：
Q1OTORHINOLARYNGOLOGYQ3MEDICINE, RESEARCH & EXPERIMENTAL
最新[2023]版：
Q1OTORHINOLARYNGOLOGYQ3MEDICINE, RESEARCH & EXPERIMENTAL
第一作者机构：[1]Department of Otolaryngology–Head and Neck Surgery, Beijing Tongren Hospital and Key Laboratory of Otolaryngology–Head and Neck Surgery, Capital Medical University, Ministry of Education, Beijing, China
通讯作者：
通讯机构：[1]Department of Otolaryngology–Head and Neck Surgery, Beijing Tongren Hospital and Key Laboratory of Otolaryngology–Head and Neck Surgery, Capital Medical University, Ministry of Education, Beijing, China[*1]Department of Otolaryngology–Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Otolaryngology–Head and Neck Surgery (Capital Medical University), Ministry of Education, No. 1 Dong Jiao Min Xiang, Dongcheng District, Beijing, 100730, P. R. China.
推荐引用方式(GB/T 7714)：
Huang Zhenxiao,Zhou Bing,Zhang Qi,et al.The role of upper and lower airway patency in chronic rhinosinusitis with nasal polyps and asthma[J].LARYNGOSCOPE.2013,123(3):569-573.doi:10.1002/lary.23649.
APA：
Huang, Zhenxiao,Zhou, Bing,Zhang, Qi,Huang, Qian,Sun, Yan...&Cui, Shunjiu.(2013).The role of upper and lower airway patency in chronic rhinosinusitis with nasal polyps and asthma.LARYNGOSCOPE,123,(3)
MLA：
Huang, Zhenxiao,et al."The role of upper and lower airway patency in chronic rhinosinusitis with nasal polyps and asthma".LARYNGOSCOPE 123..3(2013):569-573
