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Induction of a type 2 inflammatory chronic rhinosinusitis in C57BL/6 mice

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收录情况： ◇ ESCI

作者：
Li Ying[1,2,3] * ; He Ping[1,2,3,4] * ; Yan Bing[1,2,3] ; Ren Yimin[1,2,3] ; Cui Bangyu[1,2,3] ; Wang Ming[1,2,3] ; Ma Siyuan[1,2,3] ; Yang Jun[1,2,3] ; Zhang Luo[1,2,3,5] ; Wang Chengshuo[1,2,3] ;
机构： [1]Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China. [2]Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing, China. [3]Research Unit of Diagnosis and Treatment of Chronic Nasal Diseases, Chinese Academy of Medical Sciences, Beijing, China. [4]Department of Otolaryngology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. [5]Department of Allergy, Beijing TongRen Hospital, Capital Medical University, Beijing, China.
出处：
DOI： 10.5415/apallergy.0000000000000123
ISSN：

关键词： Aerosol inhalation asthma mouse model nasal instillation rhinosinusitis

摘要：
Eosinophilic chronic rhinosinusitis (CRS) has been widely studied for its intractability and high recurrence rate. It can be divided into pure and mixed type 2 CRS subtypes. Mouse models that reflect pure type 2 inflammation of CRS are lacking.This study aims to establish a relatively pure type 2 CRS mouse model and compare it with 2 mixed type 2 CRS models.Three mouse CRS models were constructed: (1) aerosol ovalbumin (OVA) + aspergillus oryzae-derived protease (AP); (2) intranasal OVA + AP; (3) Intraperitoneal then intranasal OVA + AP (n = 10 per group). Nasal, lung symptoms, IgE, inflammatory cells, cytokines, and remodeling factors were evaluated.Histological and micro-computed tomography showed inflammation, polyps, and opacification in all 3 experimental groups. The aerosol group had significantly increased local eosinophils and type 2 cytokines, while other types of cytokines showed no noticeable change. The nasal instillation groups also showed elevated other inflammatory factors and tissue polypoid changes were more pronounced. More severe pulmonary inflammation was observed with aerosol delivery.Aerosol inhalation mouse model is superior for studying nasal relatively pure type 2 inflammation and lower airway comorbidities.Copyright © 2023. Asia Pacific Association of Allergy, Asthma and Clinical Immunology.

基金：
National Key R&D Program of China (2022YFC2504100), the program for the Changjiang Scholars and Innovative Research Team (IRT13082), CAMS innovation fund for medical sciences (2019-I2M-5-022), Capital’s funds for health improvement and research (2022-1-1091), National Natural Science Foundation of China (82025010, 81630023, 82171108, 81900917, and 81870698), Beijing Municipal Administration of Hospitals’ Mission Plan (SML20150203), Beijing Municipal Administration of Hospitals’ Dengfeng plan (DFL20190202), and Dongcheng District Outstanding Talent Nurturing Program (2022-dchrcpyzz-3).
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外文
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出版当年[2021]版：
无
最新[2023]版：
Q3 ALLERGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者机构： [1]Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China. [2]Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing, China. [3]Research Unit of Diagnosis and Treatment of Chronic Nasal Diseases, Chinese Academy of Medical Sciences, Beijing, China.
共同第一作者：
通讯作者：
通讯机构： [1]Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China. [2]Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing, China. [3]Research Unit of Diagnosis and Treatment of Chronic Nasal Diseases, Chinese Academy of Medical Sciences, Beijing, China. [5]Department of Allergy, Beijing TongRen Hospital, Capital Medical University, Beijing, China.
推荐引用方式(GB/T 7714)：
Li Ying,He Ping,Yan Bing,et al.Induction of a type 2 inflammatory chronic rhinosinusitis in C57BL/6 mice[J].Asia Pacific Allergy.2023,13(4):164-174.doi:10.5415/apallergy.0000000000000123.
APA：
Li Ying,He Ping,Yan Bing,Ren Yimin,Cui Bangyu...&Wang Chengshuo.(2023).Induction of a type 2 inflammatory chronic rhinosinusitis in C57BL/6 mice.Asia Pacific Allergy,13,(4)
MLA：
Li Ying,et al."Induction of a type 2 inflammatory chronic rhinosinusitis in C57BL/6 mice".Asia Pacific Allergy 13..4(2023):164-174

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