Background The use of non-invasive clinical markers for predicting CRS recurrence is still not well investigated. Objective The aim of this study was to investigate the comprehensive effects of non-invasive clinical markers on the recurrence of CRS with nasal polyps (CRSwNP). Materials and methods A total of 346 consecutive CRSwNP patients undergoing endoscopic functional sinus surgery were recruited. The demographic characteristics and clinical parameters were recorded. Machine learning algorithm were used for evaluating the predictive value of asthma history and blood eosinophils percentage. Results Finally, 313/346 patients completed the study. The average follow-up time was 24 months after the first surgery. For the CRSwNP with asthma patients, the blood eosinophils percentage cut-off value was 3.7%. However, for the CRSwNP without asthma patients, the blood eosinophils percentage cut-off value was high, at 6.9%. Conclusion Combined asthma history and blood eosinophils percentage can predict CRSwNP recurrence, while asthma history can reduce the threshold of blood eosinophils percentage to predict CRSwNP recurrence. Significance For the CRS patients, combined asthma history and blood eosinophils percentage can predict recurrence, while asthma history can reduce the threshold of blood eosinophils percentage to predict recurrence.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81900916]; Beijing Nova ProgramBeijing Municipal Science & Technology Commission [Z201100006820043]; Beijing Municipal Administration of Hospitals' Youth Programme [QML20190208]; Priming Scientific Research Foundation for the Senior Researcher in Beijing TongRen Hospital, Capital Medical University [2017-YJJ-GGL-005]; National Key R&D Program of China [2018YFC0116800]; program for Changjiang Scholars and Innovative Research TeamProgram for Changjiang Scholars & Innovative Research Team in University (PCSIRT) [IRT13082]; CAMS Innovation Fund for Medical Sciences [2019-I2M-5-022]; Beijing municipal administration of hospitals' mission plan [SML20150203]; Beijing Municipal Administration of hospitals' Dengfeng plan [DFL20190202]; Beijing Municipal Administration of hospitals clinical medicine development of special funding support [XMLX201816]
第一作者机构：[1]Capital Med Univ, Beijing TongRen Hosp, Dept Otolaryngol Head & Neck Surg, Beijing, Peoples R China
通讯作者：
通讯机构：[1]Capital Med Univ, Beijing TongRen Hosp, Dept Otolaryngol Head & Neck Surg, Beijing, Peoples R China[2]Chinese Acad Med Sci, Res Unit Diag & Treatment Chron Nasal Dis, Beijing, Peoples R China[3]Beijing Inst Otolaryngol, Beijing Key Lab Nasal Dis, Beijing, Peoples R China[4]Capital Med Univ, Beijing TongRen Hosp, Dept Allergy, Beijing, Peoples R China[*1]Beijing Institute of Otolaryngology, No. 17, HouGouHuTong, DongCheng District, Beijing, 100005, China[*2]Department of Otolaryngology, Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China
推荐引用方式(GB/T 7714)：
Wang Xiaoyan,Meng Yifan,Lou Hongfei,et al.Blood eosinophil count combined with asthma history could predict chronic rhinosinusitis with nasal polyp recurrence[J].ACTA OTO-LARYNGOLOGICA.2021,141(3):279-285.doi:10.1080/00016489.2020.1844288.
APA：
Wang, Xiaoyan,Meng, Yifan,Lou, Hongfei,Wang, Kuiji,Wang, Chengshuo&Zhang, Luo.(2021).Blood eosinophil count combined with asthma history could predict chronic rhinosinusitis with nasal polyp recurrence.ACTA OTO-LARYNGOLOGICA,141,(3)
MLA：
Wang, Xiaoyan,et al."Blood eosinophil count combined with asthma history could predict chronic rhinosinusitis with nasal polyp recurrence".ACTA OTO-LARYNGOLOGICA 141..3(2021):279-285
