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Individual exposure of ambient particulate matters and eosinophilic chronic rhinosinusitis with nasal Polyps: Dose-Response, mediation effects and recurrence prediction

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收录情况： ◇ SCIE

作者：
Wang Jiajia[1,2] * ; Shen Shen[3,4] * ; Yan Bing[3,4] ; He Yunsheng[5] ; Zhang Guoji[6] ; Shan Chunguang[7] ; Yang Qintai[8] ; Qin Long[9] ; Duan Zhijian[10] ; Jiang Luyun[11] ; Wang Xin[12] ; Wei Xin[13] ; Wang Chengshuo[3,4,14,15] ; Chen Rui[2,16,17,*2] ; Zhang Luo[3,4,14,15,*1] ;
机构： [1]Department of Occupational and Environmental Health, School of Public Health, Capital Medical University, Beijing 100069, PR China [2]Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing 100069, PR China [3]Department of Otolaryngology, Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, PR China [4]Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing, PR China [5]Department of Otolaryngology, Huzhou Central Hospital, Huzhou, PR China [6]Department of Otolaryngology, Baoding No.1 Central Hospital, Baoding, PR China [7]Department of Otolaryngology, The Second Hospital of Hebei Medical University, Shijiazhuang, PR China [8]Department of Otorhinolaryngology-Head and Neck Surgery, Department of Allergy, Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China [9]Department of Otolaryngology, The Second Affiliated Hospital of Baotou Medical College, Baotou, PR China [10]Department of Otolaryngology, Hohhot First Hospital, Hohhot, PR China [11]Department of Otolaryngology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China [12]Department of Otorhinolaryngology-Head and Neck Surgery, The People’s Hospital of Suzhou New District, Suzhou, PR China [13]Department of Otolaryngology, Hainan General Hospital, Beijing, PR China [14]Department of Allergy, Beijing TongRen Hospital, Capital Medical University, Beijing, China [15]Research Unit of Diagnosis and Treatment of Chronic Nasal Diseases, Chinese Academy of Medical Sciences, Beijing, PR China [16]School of Public Health, Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing 100069, PR China [17]Department of Toxicology and Sanitary Chemistry, School of Public Health, Capital Medical University, Beijing 100069, PR China
出处：
DOI： 10.1016/j.envint.2023.108031
ISSN：

关键词： Chronic rhinosinusitis with nasal polyps Particulate matters Eosinophils Machine learning Prediction model

摘要：
We evaluated the association between ambient particulate matter (PM) exposure and eosinophilic chronic rhinosinusitis with nasal polyps (CRSwNP), and predicted the CRSwNP recurrence risk using machine learning algorithms.In total, 1,086 patients with CRSwNP were recruited from nine hospitals in China during 2014-2019. The average annual concentrations of ambient PMs before surgery were assessed using satellite-based daily concentrations of PM2.5 and PM10 for a 1 × 1-km2 area. Linear regression and logistic regression models were used to evaluate the associations of PM exposure with eosinophilia and risks of eosinophilic CRSwNPs. In addition, mediation effect analysis was used to validate the interrelationships of the aforementioned factors. Finally, machine learning algorithms were used to predict the recurrence risks of CRSwNPs.There was a significantly increased risk of eosinophilic CRSwNPs with each 10 μg/m3 increase in PMs, with odds ratios (ORs) of 1.039 (95% confidence interval [CI] = 1.007-1.073) for PM10 and 1.058 (95% CI = 1.007- 1.112) for PM2.5. Eosinophils had a significant mediation effect, which accounted for 52% and 35% of the relationships of CRSwNP recurrence with PM10 and PM2.5, respectively. Finally, we developed a naïve Bayesian model to predict the risk of CRSwNP recurrence based on PM exposure, inflammatory data, and patients' demographic factors.Increased PM exposure is associated with an increased risk of eosinophilic CRSwNP in China. Therefore, patients with eosinophilic CRSwNP should reduce PM exposure to mitigate its harmful impacts.Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.

基金：
This study were supported by grants from national key R&D program of China (2022YFC2504100), the National Natural Science Foundation of China (82025031); the CAMS Innovation Fund for Medical Sciences (2019-I2M-5-022); the National Key R&D Program of China (2018YFC0116800); the Research of Capital Health Security and Cultivation (Z181100001618002); , the program for the Changjiang scholars and innovative research team (IRT13082), Beijing Municipal Science & Technology Commission (Z211100002921057) and Capital’s funds for health improvement and research (2022-1-1091).
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外文
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中科院(CAS)分区：
出版当年[2022]版：
大类 | 1 区 环境科学与生态学
小类 | 1 区 环境科学
最新[2023]版：
大类 | 1 区 环境科学与生态学
小类 | 1 区 环境科学
JCR分区：
出版当年[2021]版：
Q1 ENVIRONMENTAL SCIENCES
最新[2023]版：
Q1 ENVIRONMENTAL SCIENCES

影响因子： 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

第一作者：
第一作者机构： [1]Department of Occupational and Environmental Health, School of Public Health, Capital Medical University, Beijing 100069, PR China [2]Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing 100069, PR China
共同第一作者：
通讯作者：
通讯机构： [2]Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing 100069, PR China [3]Department of Otolaryngology, Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, PR China [4]Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing, PR China [14]Department of Allergy, Beijing TongRen Hospital, Capital Medical University, Beijing, China [15]Research Unit of Diagnosis and Treatment of Chronic Nasal Diseases, Chinese Academy of Medical Sciences, Beijing, PR China [16]School of Public Health, Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing 100069, PR China [17]Department of Toxicology and Sanitary Chemistry, School of Public Health, Capital Medical University, Beijing 100069, PR China [*1]Beijing Institute of Otolaryngology, No. 17, HouGouHuTong, DongCheng District, Beijing 100005, PR China [*2]School of Public Health, Capital Medical University, Beijing, China, 100069
推荐引用方式(GB/T 7714)：
Wang Jiajia,Shen Shen,Yan Bing,et al.Individual exposure of ambient particulate matters and eosinophilic chronic rhinosinusitis with nasal Polyps: Dose-Response, mediation effects and recurrence prediction[J].ENVIRONMENT INTERNATIONAL.2023,177:108031.doi:10.1016/j.envint.2023.108031.
APA：
Wang Jiajia,Shen Shen,Yan Bing,He Yunsheng,Zhang Guoji...&Zhang Luo.(2023).Individual exposure of ambient particulate matters and eosinophilic chronic rhinosinusitis with nasal Polyps: Dose-Response, mediation effects and recurrence prediction.ENVIRONMENT INTERNATIONAL,177,
MLA：
Wang Jiajia,et al."Individual exposure of ambient particulate matters and eosinophilic chronic rhinosinusitis with nasal Polyps: Dose-Response, mediation effects and recurrence prediction".ENVIRONMENT INTERNATIONAL 177.(2023):108031

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