机构：[1]Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China首都医科大学附属北京同仁医院临床科室耳鼻咽喉-头颈外科[2]Beijing Laboratory of Allergic Diseases, Beijing Municipal Education Commission and Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otorhinolaryngology, Beijing, China首都医科大学附属北京同仁医院研究所耳鼻咽喉科研究所[3]Department of Allergy, Beijing TongRen Hospital, Capital Medical University, Beijing, China临床科室变态反应科首都医科大学附属北京同仁医院首都医科大学附属同仁医院[4]Research Unit of Diagnosis and Treatment of Chronic Nasal Diseases, Chinese Academy of Medical Sciences, Beijing, China
IntroductionChronic rhinosinusitis (CRS) is a heterogeneous disease, and its complex pathophysiological characteristics pose a challenge to its clinical treatment. CRS is distinguished not only by clinical phenotype but also by endotype characteristics, which are divided into type 2 CRS and non-type 2 CRS.Areas coveredIn this review, we summarize and discuss current studies that depict the mechanisms and endotypes of CRS. In particular, inflammatory cells and the microbiome play a role in the pathophysiology of CRS. We also listed some of the biomarkers described in recent studies that may serve as a theoretical foundation for additional investigations. We have summarized the advantages and disadvantages of existing treatments and listed the available biological treatments for CRS in detail.Expert opinionEndotype-driven therapeutic options face many challenges because of the complexity of the disease. Glucocorticoids, nasal endoscopic surgery, and biological therapy are the main treatments used in clinical practice, but they have limitations. This review provides advice on the clinical management and treatment options for patients with different endotypes, which will be more conducive to improving the quality of life and reducing the financial burden on patients.
基金：
National Key R&D Program of
China (2022YFC2504100), the Program for the Changjiang Scholars and
Innovative Research Team (IRT13082), the National Natural Science
Foundation of China (81970852, 82000962, and 82171110), the Beijing
Natural Science Foundation (7222024), the CAMS Innovation Fund for Medical Sciences (2019-I2M-5-022), the Beijing Municipal Science &
Technology Commission (Z211100002921057) and Capital’s Funds for
Health Improvement and Research (2022-1-1091), the Beijing Bai-QianWan talent project (2019A32), the Interdisciplinary cooperation project
of Beijing Science and Technology Star (20220484226), Beijing Hospitals
Authority Youth Programme (QML20230201), and the Public Welfare
Development and Reform Pilot Project (2019-10).
第一作者机构：[1]Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China[2]Beijing Laboratory of Allergic Diseases, Beijing Municipal Education Commission and Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otorhinolaryngology, Beijing, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Otolaryngology Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China[2]Beijing Laboratory of Allergic Diseases, Beijing Municipal Education Commission and Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otorhinolaryngology, Beijing, China[3]Department of Allergy, Beijing TongRen Hospital, Capital Medical University, Beijing, China[4]Research Unit of Diagnosis and Treatment of Chronic Nasal Diseases, Chinese Academy of Medical Sciences, Beijing, China[*1]Beijing Laboratory of Allergic Diseases, Beijing Municipal Education Commission and Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing 100005, China[*2]Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China
推荐引用方式(GB/T 7714)：
Sima Yutong,Zhao Yan,Wang Xiangdong,et al.Precision medicine in chronic rhinosinusitis - using endotype and endotype-driven therapeutic options[J].EXPERT REVIEW OF CLINICAL IMMUNOLOGY.2023,19(8):949-958.doi:10.1080/1744666X.2023.2232115.
APA：
Sima, Yutong,Zhao, Yan,Wang, Xiangdong&Zhang, Luo.(2023).Precision medicine in chronic rhinosinusitis - using endotype and endotype-driven therapeutic options.EXPERT REVIEW OF CLINICAL IMMUNOLOGY,19,(8)
MLA：
Sima, Yutong,et al."Precision medicine in chronic rhinosinusitis - using endotype and endotype-driven therapeutic options".EXPERT REVIEW OF CLINICAL IMMUNOLOGY 19..8(2023):949-958
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