机构：[1]Department of Neurology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China[2]Department of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, China[3]Department of Neurology, Subei People’s Hospital of Jiangsu Province, Yangzhou 225001, China[4]Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China华中科技大学同济医学院附属同济医院[5]Department of Neurology, Fujian Medical University Union Hospital, Fuzhou 350001, China[6]Department of Neurology, Tongren Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China[7]Department of Neurology, Tangshan Gongren Hospital, Tangshan 063007, China[8]Department of Neurology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China首都医科大学附属安贞医院[9]Department of Neurology, West China Hospital, Sichuan University, Chengdu 610047, China四川大学华西医院[10]Department of Neurology, Hebei General Hospital, Shijiazhuang 050051, China[11]Department of Neurology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China浙江大学医学院附属第一医院[12]Department of Neurology, The Third Medical Center of Chinese PLA General Hospital, Beijing 100039, China[13]Department of Neurology, People’s Hospital Ningxia Hui Autonomous Region, Yinchuan 750021, China[14]Department of Neurology, Beijing Hospital, National Center of Gerontology, Beijing 100730, China[15]Department of Neurology, Jining No. 1 People’s Hospital, Jining 272011, China[16]Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250021, China[17]Department of Neurology, China-Japan Union Hospital, Jilin University, Changchun 130031, China吉林大学中日联谊医院[18]Department of Neurology, Changzhi People’s Hospital, Shanxi Medical University, Changzhi 046000, China[19]Department of Neurology, Hong Xinglong Central Hospital, Shuangyashan 155811, China[20]Department of Radiology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China
Background: Intracranial atherosclerosis (ICAS) is a major cause of stroke worldwide. However, much remains unknown regarding its underlying pathophysiology. High-resolution magnetic resonance imaging (HR-MRI) can clearly display intracranial vessel wall lesions in vivo. The aim of stroke imaging package study of ICAS (SIPS-ICAS) study is to explore the stroke mechanisms of symptomatic ICAS, the dynamic changes under aggressive medical treatment and their associations with clinical events using conventional MRI sequences plus HR-MRI. Methods: This is a multicenter, prospective, cohort study recruiting first-ever acute ischemic stroke patients attributed to intracranial large artery stenosis (>50% or occlusion). Subjects undergo a pre-designed stroke imaging packages at baseline and are recommended to receive aggressive medical treatments. Participants will be followed up for functional outcome, stroke recurrence, and death events at 3, 6 and 12 months and retake HR-MRI imaging at 6 months. Results: Enrollment began in November 2018 and 96 patients have been enrolled as of September 2019. Conclusions: The SIPS-ICAS study will provide insights into the pathophysiology of ICAS and identify specific imaging markers for risk stratification and prognosis prediction. At the same time, the feasibility and validity of the new stroke imaging package including HR-MRI will be assessed, which is promising for clinical routine use.
基金：
Ministry of Science and Technology of the People's Republic of ChinaMinistry of Science and Technology, China [2017YFC1307900, 2017YFC1307902]
第一作者机构：[1]Department of Neurology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China
通讯机构：[*1]Department of Neurology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Shuaifuyuan1, Dongcheng District, Beijing 100730, China
推荐引用方式(GB/T 7714)：
Lin Qianqian,Liu Xiaoyun,Chen Beilei,et al.Design of stroke imaging package study of intracranial atherosclerosis: a multicenter, prospective, cohort study[J].ANNALS OF TRANSLATIONAL MEDICINE.2020,8(1):doi:10.21037/atm.2019.11.111.
APA：
Lin, Qianqian,Liu, Xiaoyun,Chen, Beilei,Tian, Daishi,Liu, Changyun...&Stroke Imaging Package Study of Intracranial Atherosclerosis SIPS-ICAS study group.(2020).Design of stroke imaging package study of intracranial atherosclerosis: a multicenter, prospective, cohort study.ANNALS OF TRANSLATIONAL MEDICINE,8,(1)
MLA：
Lin, Qianqian,et al."Design of stroke imaging package study of intracranial atherosclerosis: a multicenter, prospective, cohort study".ANNALS OF TRANSLATIONAL MEDICINE 8..1(2020)
