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Chinese SLE Treatment and Research Group (CSTAR) registry:VIII. Influence of socioeconomic and geographical variables on disease phenotype and activity in Chinese patients with SLE

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WOS体系：
Pubmed体系：

收录情况： ◇ SCIE

作者：
Cheng, Yongjing[1] * ; Li, Mengtao[2] * ; Zhao, Jiuliang[2] ; Ye, Zhizhong[3] ; Li, Caifeng[4] ; Li, Xiaofeng[5] ; Zhu, Ping[6] ; Wang, Zhengang[7] ; Zheng, Yi[8] ; Li, Xiangpei[9] ; Zhang, Miaojia[10] ; Huang, Cibo[1,*2] ; Zeng, Xiaofeng[2,*1] ; CSTAR co-authors[1] ;
机构： [1]Department of Rheumatology, National Center of Gerontology, Beijing Hospital, Beijing, China, [2]Department of Rheumatology, Peking Union Medical College Hospital, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China, [3]Department of Rheumatology, The Fourth People’s Hospital of Shenzhen Affiliated to Guangdong, Medical College, Guangdong, China, [4]Department of Rheumatology, Beijing Children’s Hospital Affiliated to Capital Medical University, Beijing, China, [5]Department of Rheumatology, The Second Hospital of Shanxi Medical University, Shanxi, China, [6]Department of Clinical Immunology and Rheumatology, Xijing Hospital affiliated to the Fourth Military Medical University, Shanxi, China, [7]Department of Rheumatology, Beijing Tongren Hospital Affiliated to Capital Medical University, Beijing, China, [8]Department of Rheumatology, Beijing Chao-Yang Hospital Affiliated to Capital Medical University, Beijing, China, [9]Department of Rheumatology, Anhui Provincial Hospital, Anhui, China, [10]Department of Rheumatology, Jiangsu Provincial People’s Hospital, Jiangsu, China
出处：
DOI： 10.1111/1756-185X.13057
ISSN：

关键词： geographical variable lupus nephritis SLEDAI socioeconomic status systemic lupus erythematous

摘要：
AimThe aim of this study was to estimate the influence of socioeconomic and geographical variables on disease phenotype and activity of systemic lupus erythematosus (SLE) in a Chinese population. MethodsData on 904 therapy-naive SLE patients from the Chinese SLE Treatment and Research Group (CSTAR), which is a nation-wide database of SLE patients, were used to evaluate the influence of socioeconomic status (SES) and geographical regions on disease phenotypes. The influence of regional climate and economic variables (i.e., data from the database of the Chinese Statistical Yearly Annals) on disease activity and nephropathy was further analyzed in a multivariate analysis to identify some of the environmental factors contributing to SLE. ResultsPhenotype differences in SLE were found between patients with different SES. In the multivariate regression analysis that considered regional economic and climate factors, after adjusting for age, gender and disease duration, lower educational levels (: -0.122, P = 0.001), lower availability of medical technical personnel (MTP) per 1000 people (: -0.192, P < 0.001), higher annual duration of sunshine (: 0.178, P = 0.010) and residence in southern China (: 0.165, P = 0.001) were significantly associated with higher disease activity scores. Living in southern China (odds ratio [OR]: 1.907, P = 0.002) seemed to be a significant risk factor for nephropathy. A high number of MTP per 1000 people (OR: 0.951, P = 0.014) and relatively high temperatures were determined to be protective factors for nephropathy (OR: 0.946, P = 0.011). ConclusionsThe phenotype pattern and disease activity varied between SLE patients by SES and other regional variables, such as educational level, availability of medical technical personnel, annual sunshine duration and regional temperature.

基金：
Chinese National Key Technology R&D Program, Ministry of Science and Technology [2008BAI59B02, 2011BAI11B15]; Chinese National High Technology Research and Development Program, Ministry of Science and TechnologyNational High Technology Research and Development Program of China [2012AA02A513]; Research Special Fund for Public Welfare Industry of Health, Ministry of Health [201202004]; National Major Scientific and Technological Special Project for 'Significant New Drugs Development', Ministry of Science and Technology [2012ZX09303006-002]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类 | 4 区 医学
小类 | 4 区 风湿病学
最新[2023]版：
大类 | 4 区 医学
小类 | 4 区 风湿病学
JCR分区：
出版当年[2016]版：
Q3 RHEUMATOLOGY
最新[2023]版：
Q2 RHEUMATOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2016版] 出版当年五年平均 出版前一年[2015版] 出版后一年[2017版]

第一作者：
第一作者机构： [1]Department of Rheumatology, National Center of Gerontology, Beijing Hospital, Beijing, China,
共同第一作者：
通讯作者：
通讯机构： [1]Department of Rheumatology, National Center of Gerontology, Beijing Hospital, Beijing, China, [2]Department of Rheumatology, Peking Union Medical College Hospital, Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education, Beijing, China, [*1]Department of Rheumatology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China. [*2]Department of Rheumatology and Immunology, Beijing Hospital, National Center of Gerontology, China.
推荐引用方式(GB/T 7714)：
Cheng Yongjing,Li Mengtao,Zhao Jiuliang,et al.Chinese SLE Treatment and Research Group (CSTAR) registry:VIII. Influence of socioeconomic and geographical variables on disease phenotype and activity in Chinese patients with SLE[J].INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES.2018,21(3):716-724.doi:10.1111/1756-185X.13057.
APA：
Cheng, Yongjing,Li, Mengtao,Zhao, Jiuliang,Ye, Zhizhong,Li, Caifeng...&CSTAR co-authors.(2018).Chinese SLE Treatment and Research Group (CSTAR) registry:VIII. Influence of socioeconomic and geographical variables on disease phenotype and activity in Chinese patients with SLE.INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES,21,(3)
MLA：
Cheng, Yongjing,et al."Chinese SLE Treatment and Research Group (CSTAR) registry:VIII. Influence of socioeconomic and geographical variables on disease phenotype and activity in Chinese patients with SLE".INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES 21..3(2018):716-724

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