The main purpose of this study was to explore treatment effect of hydroxychloroquine-loaded OX7 nanoliposomes in murine systemic lupus erythematosus (SLE) disease model. Modification of OX7 monoclonal antibody conferred hydroxychloroquine-loaded OX7 nanoliposomes targeting to renal mesangial cells. The SLE mice models were treated with functional nano liposome via tail vein injection, and then the therapeutic effects on lupus nephritis and complicated pneumonia were evaluated. Our research showed that chronic graft versus host disease lupus nephritis mice model has similar characteristic features of renal pathological damage with human SLE, and is reliable for related study. The symptoms and incidence of pneumonia in model mice were significantly alleviated and reduced after treatment with functional nano liposomes prepared in this experiment.
第一作者机构：[1]Shanghai Univ, Inst Translat Med, Shanghai 200444, Peoples R China
通讯作者：
推荐引用方式(GB/T 7714)：
Chen Dagui,Shang Fusheng,Zhang Shuyan,et al.Construction of Functional Renal Targeting Nano Drug Liposome and Its Effect on Lupus Nephritis[J].NANOSCIENCE AND NANOTECHNOLOGY LETTERS.2020,12(12):1386-1391.doi:10.1166/nnl.2020.3262.
APA：
Chen, Dagui,Shang, Fusheng,Zhang, Shuyan&Zhang, Danhuan.(2020).Construction of Functional Renal Targeting Nano Drug Liposome and Its Effect on Lupus Nephritis.NANOSCIENCE AND NANOTECHNOLOGY LETTERS,12,(12)
MLA：
Chen, Dagui,et al."Construction of Functional Renal Targeting Nano Drug Liposome and Its Effect on Lupus Nephritis".NANOSCIENCE AND NANOTECHNOLOGY LETTERS 12..12(2020):1386-1391
