PurposeTo compare the orbital cerebral spinal fluid pressure (CSFP) and trans-lamina cribrosa pressure difference (TLCPD) determined noninvasively in ocular hypertensive (OH) subjects and controls. MethodsCross-sectional observational study. Magnetic resonance imaging was used to measure orbital subarachnoid space width (OSASW). The CSFP (mmHg) was estimated from a published formula as 17.54xMRI derived OSASW at 15mm behind the globe+0.47xbody mass index+0.13xmean arterial blood pressure -21.52. Estimated TLCPD was calculated as IOP- CSFP. ResultsThe orbital subarachnoid space width was significantly wider (p=0.01) in the OH group than in the control group at all three measurement locations. The MRI derived CSFP value in OH (14.92.9mmHg) was significantly higher than in the normal group (12.0 +/- 2.8mmHg; p<0.01). The estimated TLCPD value in OH (9.0 +/- 4.2mmHg) was significantly higher than in controls (3.6 +/- 3.0mmHg; p<0.01). ConclusionThe wider OSASW and higher estimated CSFP in OH subjects suggest a higher orbital CSFP. Despite a higher orbital CSFP that could be protective, the higher TLCPD in OH may play a significant role in the risk of developing glaucoma.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81271005, 81400391]; Beijing Natural Science FoundationBeijing Natural Science Foundation [7122038]; Award of Excellent Doctoral Dissertation in Beijing (Beijing YXBS Grant) [PXM2010_014226_07_000061, PXM2011_014 226_07_000114]; Beijing Municipal Administration of Hospital's Youth Programme [QML20160203]
第一作者机构：[1]China Acad Chinese Med Sci, Hosp Eye, 33 Lugu Rd, Beijing 100040, Peoples R China
共同第一作者：
通讯作者：
通讯机构：[1]China Acad Chinese Med Sci, Hosp Eye, 33 Lugu Rd, Beijing 100040, Peoples R China[2]Capital Med Univ, Beijing Tongren Hosp, Beijing Inst Ophthalmol, 17 Hougou Lane, Beijing 100005, Peoples R China[3]Capital Med Univ, Beijing Ophthalmol & Visual Sci Key Lab, Beijing Tongren Hosp, Beijing Tongren Eye Ctr, 1 Dongjiaominxiang St, Beijing 100730, Peoples R China[*1]Beijing Tongren Eye Center Beijing Tongren Hospital Capital Medical University Beijing Ophthalmology and Visual Sciences Key Laboratory 1 Dongjiaominxiang Street, Dongcheng District Beijing 100730 China[*2]Beijing Institute of Ophthalmology Capital Medical University Beijing Tongren Hospital 17 Hougou Lane, Chongwenmen Beijing, 100005 China[*3]Eye Hospital of China Academy of Chinese Medical Sciences 33 Lugu Road, Shijingshan District Beijing, 100040 China
推荐引用方式(GB/T 7714)：
Xie Xiaobin,Chen Weiwei,Li Zhen,et al.Noninvasive evaluation of cerebrospinal fluid pressure in ocular hypertension: a preliminary study[J].ACTA OPHTHALMOLOGICA.2018,96(5):E570-E576.doi:10.1111/aos.13724.
APA：
Xie, Xiaobin,Chen, Weiwei,Li, Zhen,Thomas, Ravi,Li, Yong...&Wang, Ningli.(2018).Noninvasive evaluation of cerebrospinal fluid pressure in ocular hypertension: a preliminary study.ACTA OPHTHALMOLOGICA,96,(5)
MLA：
Xie, Xiaobin,et al."Noninvasive evaluation of cerebrospinal fluid pressure in ocular hypertension: a preliminary study".ACTA OPHTHALMOLOGICA 96..5(2018):E570-E576
