机构：[1]Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China研究所眼科研究所首都医科大学附属北京同仁医院首都医科大学附属同仁医院[2]Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University of Heidelberg, Mannheim, Germany[3]Beijing Tongren Eye Center, Beijing Tongren Hospital, Beijing Ophthalmology and Visual Sciences Key Laboratory, Capital Medical University, Beijing, China首都医科大学附属北京同仁医院首都医科大学附属同仁医院
Purpose: To examine whether an estimated trans-lamina cribrosa pressure difference (TLCPD) better than intraocular pressure (IOP) correlated with markers for glaucoma. Methods: The population-based Beijing Eye Study 2011 included 3468 individuals. Cerebrospinal fluid pressure (CSFP) was calculated as CSFP [mmHg] = 0.44 x Body Mass Index [kg/m(2)] + 0.16 x Diastolic Blood Pressure [mmHg] - 0.18 x Age [Years] - 1.91. TLCPD was IOP-CSFP. Results: In the non-glaucomatous population, mean TLCPD was 5.8 +/- 4.1 mmHg and mean estimated CSFP was 8.9 +/- 3.7 mmHg. IOP was higher (p = 0.008), CSFP was lower (p < 0.001), and TLCPD was (p < 0.001) higher in the glaucoma group than in the non-glaucomatous group. The intergroup difference was highest for TLCPD (2.1 mmHg) followed by CSFP (1.7 mmHg) and IOP (0.4 mmHg). Open-angle glaucoma (OAG) was associated with higher TLCPD [p < 0.001; odds ratio (OR): 1.14; 95% confidence intervals (CI): 1.08, 1.19] but not with IOP (p = 0.22; OR: 0.96; 95% CI: 0.89, 1.03). In contrast, angle-closure glaucoma (ACG) was associated with higher IOP (p = 0.03; B: 0.14; OR: 1.15; 95% CI: 1.01, 1.30) but not with TLCPD (p = 0.98), after adjustment for age and anterior chamber depth. Retinal nerve fibre layer thickness was associated with lower TLCPD (p = 0.036) but not with IOP (p = 0.96), after adjusting for gender, age, region of habitation, optic disc area and refractive error. Neuroretinal area and volume were associated with smaller TLCPD (p = 0.002, and p < 0.001, respectively), after adjusting for gender, optic disc area and refractive error, but not with IOP (p = 0.43 and p = 0.25, resp.). Conclusions: In OAG, but not in ACG, calculated TLCPD versus IOP showed a better association with glaucoma presence and amount of glaucomatous optic neuropathy. It supports the notion of a potential role of low CSFP in the pathogenesis of OAG.
基金：
National Natural Science Foundation of China [81170890]
第一作者机构：[1]Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China[2]Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University of Heidelberg, Mannheim, Germany
通讯作者：
通讯机构：[1]Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China[*1]Beijing Institute of Ophthalmology 17 Hougou Lane Chong Wen Men 100005 Beijing, China
推荐引用方式(GB/T 7714)：
Jonas Jost B.,Wang Ning Li,Wang Ya Xing,et al.Estimated trans-lamina cribrosa pressure difference versus intraocular pressure as biomarker for open-angle glaucoma. The Beijing Eye Study 2011[J].ACTA OPHTHALMOLOGICA.2015,93(1):E7-E13.doi:10.1111/aos.12480.
APA：
Jonas, Jost B.,Wang, Ning Li,Wang, Ya Xing,You, Qi Sheng,Xie, Xiao Bin...&Xu, Liang.(2015).Estimated trans-lamina cribrosa pressure difference versus intraocular pressure as biomarker for open-angle glaucoma. The Beijing Eye Study 2011.ACTA OPHTHALMOLOGICA,93,(1)
MLA：
Jonas, Jost B.,et al."Estimated trans-lamina cribrosa pressure difference versus intraocular pressure as biomarker for open-angle glaucoma. The Beijing Eye Study 2011".ACTA OPHTHALMOLOGICA 93..1(2015):E7-E13
