机构：[1]Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, BeijingTongren Hospital, Capital Medical University, Beijing Ophthalmology andVisual Science Key Lab, Beijing, China研究所眼科研究所首都医科大学附属北京同仁医院首都医科大学附属同仁医院[2]Department of Ophthalmology,Medical Faculty Mannheim of the Ruprecht-Karls-University, Heidelberg,Germany[3]Beijing Tongren Eye Center, Beijing Tongren Hospital, CapitalMedical University, Beijing Ophthalmology and Visual Sciences KeyLaboratory, Beijing, China首都医科大学附属北京同仁医院首都医科大学附属同仁医院[4]Beijing Tongren Eye Center, Beijing TongrenHospital, Capital Medical University, Beijing, China.首都医科大学附属北京同仁医院首都医科大学附属同仁医院
BACKGROUND Hypertensive retinal microvascular abnormalities include an increased retinal vein-to-artery diameter ratio. Because central retinal vein pressure depends on cerebrospinal fluid pressure (CSFP), we examined whether the retinal vein-to-artery diameter ratio and other retinal hypertensive signs are associated with CSFP. METHODS Participants of the population-based Beijing Eye Study (n = 1,574 subjects) underwent measurement of the temporal inferior and superior retinal artery and vein diameter. CSFP was calculated as 0.44 x body mass index (kg/m(2)) + 0.16 x diastolic blood pressure (mm Hg) - 0.18 x age (years) - 1.91. RESULTS Larger retinal vein diameters and higher vein-to-artery diameter ratios were significantly associated with higher estimated CSFP (P = 0.001) in multivariable analysis. In contrast, temporal inferior retinal arterial diameter was marginally associated (P = 0.03) with estimated CSFP, and temporal superior artery diameter was not significantly associated (P = 0.10) with estimated CSFP; other microvascular abnormalities, such as arteriovenous crossing signs, were also not significantly associated with estimated CSFP. In a reverse manner, higher estimated CSFP as a dependent variable in the multivariable analysis was associated with wider retinal veins and higher vein-to-artery diameter ratio. In the same model, estimated CSFP was not significantly correlated with retinal artery diameters or other retinal microvascular abnormalities. Correspondingly, arterial hypertension was associated with retinal microvascular abnormalities such as arteriovenous crossing signs (P = 0.003), thinner temporal retinal arteries (P < 0.001), higher CSFP (P < 0.001), and wider retinal veins (P = 0.001) or, as a corollary, with a higher vein-to-artery diameter ratio in multivariable analysis. CONCLUSIONS Wider retinal vein diameters are associated with higher estimated CSFP and vice versa. In arterial hypertension, an increased retinal vein-to-artery diameter ratio depends on elevated CSFP, which is correlated with blood pressure.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81770890]; Beijing NOVA ProgramBeijing Municipal Science & Technology Commission [2011058]; National Key Technology R&D Program of the Ministry of Science and TechnologyNational Key Technology R&D Program [2012BAH05F05, 2013BAH19F04]
第一作者机构：[1]Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, BeijingTongren Hospital, Capital Medical University, Beijing Ophthalmology andVisual Science Key Lab, Beijing, China[2]Department of Ophthalmology,Medical Faculty Mannheim of the Ruprecht-Karls-University, Heidelberg,Germany
通讯作者：
推荐引用方式(GB/T 7714)：
Jonas Jost B.,Wang Ningli,Wang Shuang,et al.Retinal Vessel Diameter and Estimated Cerebrospinal Fluid Pressure in Arterial Hypertension: The Beijing Eye Study[J].AMERICAN JOURNAL OF HYPERTENSION.2014,27(9):1170-1178.doi:10.1093/ajh/hpu037.
APA：
Jonas, Jost B.,Wang, Ningli,Wang, Shuang,Wang, Ya Xing,You, Qi Sheng...&Xu, Liang.(2014).Retinal Vessel Diameter and Estimated Cerebrospinal Fluid Pressure in Arterial Hypertension: The Beijing Eye Study.AMERICAN JOURNAL OF HYPERTENSION,27,(9)
MLA：
Jonas, Jost B.,et al."Retinal Vessel Diameter and Estimated Cerebrospinal Fluid Pressure in Arterial Hypertension: The Beijing Eye Study".AMERICAN JOURNAL OF HYPERTENSION 27..9(2014):1170-1178
