机构：[1]Department of Pediatrics, Beijing Tongren Hospital, Capital Medical University, Beijing 100176临床科室儿科首都儿科研究所首都医科大学附属北京同仁医院首都医科大学附属同仁医院[2]Key Laboratory of Major Diseases in Children, Ministry of Education, Department of Hematology, Beijing Children's Hospital, Capital Medical University, Beijing 100045, P.R. China首都医科大学附属北京儿童医院
The prognostic significance of microRNA (miR)-210 and the caspase 8-associated protein 2 (CASP8AP2) gene in children with acute lymphoblastic leukemia (ALL) has been validated and CASP8AP2 has been demonstrated as a target of miR-210. In the present study, the reverse transcription-quantitative polymerase chain reaction (RT-qPCR) was used to determine miR-210 and CASP8AP2 expression in 91 children with ALL. Associations between gene expression levels and the prognostic value of combined detection of the two indicators were analyzed. Results from a receiver operating characteristic curve demonstrated that threshold values of miR-210 and CASP8AP2 were 3.8243 and 0.4760, respectively. Although the expression of miR-210 and CASP8AP2 were not associated at the mRNA level in pediatric ALL, combined detection of the two predicted ALL prognosis with an increased accuracy. Furthermore, an equation was devised including minimal residual disease at day 33 and expression of miR-210 and CASP8AP2, which may enable bone marrow relapse to be predicted more precisely compared with the current risk stratification.
基金：
Priming Scientific Research Foundation for the Junior Researcher in Beijing Tongren Hospital, Capital Medical University [2014-YJJ-ZZL-011]; Key Scientific Research Training Fund of Beijing Tongren Hospital, Capital Medical University [2015-YJJ-GGL-009]
第一作者机构：[1]Department of Pediatrics, Beijing Tongren Hospital, Capital Medical University, Beijing 100176
通讯作者：
通讯机构：[1]Department of Pediatrics, Beijing Tongren Hospital, Capital Medical University, Beijing 100176[*1]Department of Pediatrics, Beijing Tongren Hospital, Capital Medical University, 8 Chongwenmen Street, Dongcheng, Beijing 100176, P.R. China
推荐引用方式(GB/T 7714)：
Mei Yanyan,Li Zhigang,Zhang Yi,et al.Low miR-210 and CASP8AP2 expression is associated with a poor outcome in pediatric acute lymphoblastic leukemia[J].ONCOLOGY LETTERS.2017,14(6):8072-8077.doi:10.3892/ol.2017.7229.
APA：
Mei, Yanyan,Li, Zhigang,Zhang, Yi,Zhang, Weiling,Hu, Huimin...&Huang, Dongsheng.(2017).Low miR-210 and CASP8AP2 expression is associated with a poor outcome in pediatric acute lymphoblastic leukemia.ONCOLOGY LETTERS,14,(6)
MLA：
Mei, Yanyan,et al."Low miR-210 and CASP8AP2 expression is associated with a poor outcome in pediatric acute lymphoblastic leukemia".ONCOLOGY LETTERS 14..6(2017):8072-8077
