Enhanced recovery after surgery for radical cystectomy with ileal urinary diversion: a multi-institutional, randomized, controlled trial from the Chinese bladder cancer consortium
机构:[1]Department of Urology, Sun Yat‑sen Memorial Hospital, Sun Yat-sen University, 107 W Yanjiang Road, Yuexiu District, Guangzhou 510120, Guangdong, China中山大学附属第二医院[2]Department of Urology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China[3]Department of Urology, Southwest Hospital, Third Military Medical University, Chongqing, China[4]Department of Urology, Xiangya Hospital of Central South University, Changsha, Hunan, China[5]Department of Urology, The Third Affiliated Hospital, Third Military Medical University, Chongqing, China[6]Department of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan, China四川大学华西医院[7]Department of Urology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China重庆医科大学附属第一医院[8]Department of Urology, Chinese PLA General Hospital, Beijing, China[9]Department of Urology, Ruijin Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China[10]Department of Urology, Renji Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China[11]Department of Urology, Affiliated Hospital of Chengdu University, Chengdu, Sichuan, China[12]Department of Urology, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, China[13]Department of Urology, Beijing Friendship Hospital, Capital Medical University, Beijing, China首都医科大学附属北京友谊医院[14]Department of Urology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China[15]Department of Urology, Qilu Hospital of Shandong University, Jinan, Shandong, China[16]Department of Urology, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China[17]Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China[18]Department of Urology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China[19]Department of Urology, Shanghai Changhai Hospital of Second Military Medical University, Shanghai, China[20]Department of Urology, Peking University First Hospital, Beijing, China[21]Department of Urology, Fujian Medical University Union Hospital, Fuzhou, Fujian, China[22]Department of Urology, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China[23]Department of Urology, Wuhan General Hospital of Guangzhou Military Command, Wuhan, Hubei, China[24]Department of Urology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China中山大学附属第三医院[25]Department of Urology, Beijing Tongren Hospital, Capital Medical University, Beijing, China临床科室泌尿外科首都医科大学附属北京同仁医院首都医科大学附属同仁医院[26]Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat‑sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China中山大学附属第二医院
Enhanced recovery after surgery (ERAS) has played an important role in recovery management for radical cystectomy with ileal urinary diversion (RC-IUD). This study is to evaluate ERAS compared with the conventional recovery after surgery (CRAS) for RC-IUD. From October 2014 and July 2016, bladder cancer patients scheduled for curative treatment from 25 centers of Chinese Bladder Cancer Consortium were randomly assigned to either ERAS or CRAS group. Primary endpoint was the 30-day complication rate. Secondary endpoints included recovery of fluid and regular diet, flatus, bowel movement, ambulation, and length of stay (LOS) postoperatively. Follow-up period was 30-day postoperatively. There were 144 ERAS and 145 CRAS patients. Postoperative complications occurred in 25.7 and 30.3% of the ERAS and CRAS patients with 55 complications in each group, respectively (p = 0.40). There was no significant difference between groups in major complications (p = 0.82), or type of complications (p = 0.99). The ERAS group had faster recovery of bowel movements (median 88 versus 100 h, p = 0.01), fluid diet tolerance (68 versus 96 h, p < 0.001), regular diet tolerance (125 versus 168 h, p = 0.004), and ambulation (64 versus 72 h, p = 0.047) than the CRAS group, but similar time to flatus and LOS. ERAS did not increase 30-day complications compared with CRAS after RC. ERAS may be better than CRAS in terms of bowel movement, tolerance of fluid and regular diet, and ambulation.
基金:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81572514, U1301221, 81472384, 81402106, 81372729, 81272808, 81172431]; National Natural Science Foundation of GuangdongNational Natural Science Foundation of Guangdong Province [2016A030313321, 2015A030311011, 2015A030310122, S2013020012671, 07117336, 10151008901000024, 2015A030310091, 2016A030313185]; Science and Technology Program of Guangzhou [201604020156, 201604020177]; "Three Big Constructions" funds of Sun Yat-sen University; Specialized Research Fund for the Doctoral Program of Higher EducationSpecialized Research Fund for the Doctoral Program of Higher Education (SRFDP) [20130171110073]; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities; Guangdong Province Higher Vocational Colleges & Schools Pearl River Scholar Funded Scheme; Elite Young Scholars Program of Sun Yat-Sen Memorial Hospital [J201401]; National Clinical Key Specialty Construction Project for Department of Urology; National Clinical Key Specialty Construction Project for Department of Oncology; Key Laboratory of Malignant Tumor Gene Regulation and Target Therapy of Guangdong Higher Education Institutes, Sun Yat-sen University [KLB09001]; Key Laboratory of Malignant Tumor Molecular Mechanism and Translational Medicine of Guangzhou Bureau of Science and Information Technology [[2013]163]
第一作者机构:[1]Department of Urology, Sun Yat‑sen Memorial Hospital, Sun Yat-sen University, 107 W Yanjiang Road, Yuexiu District, Guangzhou 510120, Guangdong, China
共同第一作者:
通讯作者:
通讯机构:[1]Department of Urology, Sun Yat‑sen Memorial Hospital, Sun Yat-sen University, 107 W Yanjiang Road, Yuexiu District, Guangzhou 510120, Guangdong, China[26]Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat‑sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China
推荐引用方式(GB/T 7714):
Lin Tianxin,Li Kaiwen,Liu Hao,et al.Enhanced recovery after surgery for radical cystectomy with ileal urinary diversion: a multi-institutional, randomized, controlled trial from the Chinese bladder cancer consortium[J].WORLD JOURNAL OF UROLOGY.2018,36(1):41-50.doi:10.1007/s00345-017-2108-3.
APA:
Lin, Tianxin,Li, Kaiwen,Liu, Hao,Xue, Xueyi,Xu, Ning...&Huang, Jian.(2018).Enhanced recovery after surgery for radical cystectomy with ileal urinary diversion: a multi-institutional, randomized, controlled trial from the Chinese bladder cancer consortium.WORLD JOURNAL OF UROLOGY,36,(1)
MLA:
Lin, Tianxin,et al."Enhanced recovery after surgery for radical cystectomy with ileal urinary diversion: a multi-institutional, randomized, controlled trial from the Chinese bladder cancer consortium".WORLD JOURNAL OF UROLOGY 36..1(2018):41-50