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Loss of melanopsin-containing retinal ganglion cells in a rat glaucoma model

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收录情况: ◇ SCIE ◇ 统计源期刊 ◇ 中华系列

机构: [1]Capital Med Univ, Tongren Eye Ctr, Beijing Tongren Hosp, Beijing 100730, Peoples R China [2]Univ Nebraska, Med Ctr, Dept Ophthalmol & Visual Sci, Omaha, NE 68198 USA
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关键词: melanopsin retinal ganglion cells intraocular pressure

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Background Glaucoma can cause progressive damage to retinal ganglion cells. These cells can be classified as cells projecting to the superior colliculus and melanopsin-containing retinal ganglion cells, which project to the suprachiasmatic nucleus. This study was to investigate the effects of chronic intraocular pressure elevation on melanopsin-containing retinal ganglion cells in rats. Methods Chronic intraocular pressure elevation was induced in one eye of adult Wistar rats by cauterization of three episcleral veins. Intraocular pressure was measured at different intervals with a rebound tonometer. Superior collicular retinal ganglion cells were retrogradely labeled from the superior colliculus with Fluorogold. Melanopsin-containing retinal ganglion cells were visualized by free-floating immunohistochemistry on whole-mount retinas. The number of labeled superior collicular and melanopsin-containing retinal ganglion cells were counted in the sample areas on flat-mounted retinas. Results Compared with contralateral control eyes, the numbers of both superior collicular and melanopsin-containing retinal ganglion cells were significantly reduced after 12 weeks of experimental intraocular pressure elevation ((2317.41 +/- 29.96)/mm(2) VS (1815.82 +/- 24.25)/mm(2); (26.20 +/- 2.10)/mm(2) VS (20.62 +/- 1.52)/mm(2), respectively). The extent of cell loss of the two types of retinal ganglion cells was similar. However, no morphologic changes were found in melanopsin-containing retinal ganglion cells. Conclusion Both melanopsin-containing and superior collicular retinal ganglion cells were damaged by chronic ocular hypertension, indicating that glaucomatous neural degeneration involves the non-image-forming visual pathway.

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出版当年[2007]版:
大类 | 4 区 医学
最新[2023]版:
大类 | 3 区 医学
小类 | 3 区 医学:内科
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出版当年[2006]版:
Q3 MEDICINE, GENERAL & INTERNAL
最新[2023]版:
Q1 MEDICINE, GENERAL & INTERNAL

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第一作者机构: [1]Capital Med Univ, Tongren Eye Ctr, Beijing Tongren Hosp, Beijing 100730, Peoples R China
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