CTNNB1 (or beta-catenin) is regarded as a central effecter in molecules of the wingless/Wntsignalling pathway. It is a key component of the
cadherin mediated cell to cell adhesion system and
forms a complex with the protein product of
adenomatous polyposis
coli
(APC)，glycogen
synthase kinase 3β (GSK3β) and conductin. 1
One
mutation of APC is also responsible for activation of
winglessWnt signalling pathway and accumulation
of free beta-catenin in the cell. Beta-catenin
upregulates oncogenes, such as cyclin D1 and
C-myc.? Beta-catenin expression in cytoplasm and
nuclei was reported to increase in many cases of
3.4
intestinal
tumorigenesis.
In adition, the
hyperexpression of integrin linked kinase (ILK) in
colonic polyposis has been demonstrated.
第一作者机构：[1]Capital Univ Med Sci, Affiliated Beijing Tongren Hosp, Beijing Otolaryngol Head & Neck Surg Res Ctr, Beijing 100005, Peoples R China[2]Hamamatsu Univ Sch Med, Dept Surg 2, Hamamatsu, Shizuoka 4313192, Japan
通讯作者：
通讯机构：[1]Capital Univ Med Sci, Affiliated Beijing Tongren Hosp, Beijing Otolaryngol Head & Neck Surg Res Ctr, Beijing 100005, Peoples R China[2]Hamamatsu Univ Sch Med, Dept Surg 2, Hamamatsu, Shizuoka 4313192, Japan
推荐引用方式(GB/T 7714)：
Qiu Zhe-fu,Maruyama Keiji,Han De-min,et al.Correlation of the nuclear accumulation of CTNNB1 and colonic tumorigenesis[J].CHINESE MEDICAL JOURNAL.2006,119(13):1113-1117.doi:10.1097/00029330-200607010-00011.
APA：
Qiu Zhe-fu,Maruyama Keiji,Han De-min&Nakamura Satoshi.(2006).Correlation of the nuclear accumulation of CTNNB1 and colonic tumorigenesis.CHINESE MEDICAL JOURNAL,119,(13)
MLA：
Qiu Zhe-fu,et al."Correlation of the nuclear accumulation of CTNNB1 and colonic tumorigenesis".CHINESE MEDICAL JOURNAL 119..13(2006):1113-1117
