机构:[1]Capital Med Univ, Beijing Tongren Hosp, Dept Haematol, Beijing 100730, Peoples R China临床科室血液内科首都医科大学附属北京同仁医院首都医科大学附属同仁医院[2]Beihang Univ, Beijing Adv Innovat Ctr Big Data Based Precis Med, Beijing, Peoples R China[3]Capital Med Univ, Beijing Tongren Hosp, Beijing, Peoples R China首都医科大学附属北京同仁医院首都医科大学附属同仁医院
We retrospectively analyzed the treatment outcomes of elderly patients (aged >= 60 years) with extranodal natural killer/T-cell lymphoma, nasal type (ENKTL) and investigated the prognostic factors. Fifty-two elderly patients received chemotherapy alone, radiotherapy alone, or chemotherapy followed by radiotherapy +/- consolidation chemotherapy as induction therapy. Overall, 97.26% patients in stage I/II had overall response (OR) and 86.1% had complete response (CR), whereas 71.4% of patients in stage III/IV had OR and 35.7% had CR. The 3-year freedom from progression (FFP) rate and overall survival (OS) rate of patients with stage I/II were 78.2% and 85.0%, respectively, and those with stage III/IV were 23.3% and 33.3%. Following multivariate analysis of Cox regression, ECOG performance status scores of 3-4 and stage III/IV were independent prognostic factors for elderly ENKTL patients. Elderly patients with stage I/II or stage III/IV and good or poor performance status can benefit from the commonly used or personalized treatment.
基金:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81873450]; Open Research Fund from Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, Beijing Tongren Hospital, Beihang University & Capital Medical University [BHTR-KFJJ-202009]
第一作者机构:[1]Capital Med Univ, Beijing Tongren Hosp, Dept Haematol, Beijing 100730, Peoples R China
通讯作者:
通讯机构:[1]Capital Med Univ, Beijing Tongren Hosp, Dept Haematol, Beijing 100730, Peoples R China[2]Beihang Univ, Beijing Adv Innovat Ctr Big Data Based Precis Med, Beijing, Peoples R China[3]Capital Med Univ, Beijing Tongren Hosp, Beijing, Peoples R China[*1]Department of Haematology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China
推荐引用方式(GB/T 7714):
Wei Liqiang,Wang Liang,Cong Jia,et al.Treatment outcomes and prognostic analysis of elderly patients with extranodal natural killer/T-cell lymphoma, nasal type: a retrospective analysis[J].LEUKEMIA & LYMPHOMA.2020,61(12):2962-2968.doi:10.1080/10428194.2020.1791848.
APA:
Wei, Liqiang,Wang, Liang,Cong, Jia,Yang, Lei,Ye, Jin...&Wang, Jingwen.(2020).Treatment outcomes and prognostic analysis of elderly patients with extranodal natural killer/T-cell lymphoma, nasal type: a retrospective analysis.LEUKEMIA & LYMPHOMA,61,(12)
MLA:
Wei, Liqiang,et al."Treatment outcomes and prognostic analysis of elderly patients with extranodal natural killer/T-cell lymphoma, nasal type: a retrospective analysis".LEUKEMIA & LYMPHOMA 61..12(2020):2962-2968