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Treatment outcomes and prognostic analysis of elderly patients with extranodal natural killer/T-cell lymphoma, nasal type: a retrospective analysis

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机构: [1]Capital Med Univ, Beijing Tongren Hosp, Dept Haematol, Beijing 100730, Peoples R China [2]Beihang Univ, Beijing Adv Innovat Ctr Big Data Based Precis Med, Beijing, Peoples R China [3]Capital Med Univ, Beijing Tongren Hosp, Beijing, Peoples R China
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关键词: Extranodal natural killer T-cell lymphoma nasal type elderly treatment outcome prognosis

摘要:
We retrospectively analyzed the treatment outcomes of elderly patients (aged >= 60 years) with extranodal natural killer/T-cell lymphoma, nasal type (ENKTL) and investigated the prognostic factors. Fifty-two elderly patients received chemotherapy alone, radiotherapy alone, or chemotherapy followed by radiotherapy +/- consolidation chemotherapy as induction therapy. Overall, 97.26% patients in stage I/II had overall response (OR) and 86.1% had complete response (CR), whereas 71.4% of patients in stage III/IV had OR and 35.7% had CR. The 3-year freedom from progression (FFP) rate and overall survival (OS) rate of patients with stage I/II were 78.2% and 85.0%, respectively, and those with stage III/IV were 23.3% and 33.3%. Following multivariate analysis of Cox regression, ECOG performance status scores of 3-4 and stage III/IV were independent prognostic factors for elderly ENKTL patients. Elderly patients with stage I/II or stage III/IV and good or poor performance status can benefit from the commonly used or personalized treatment.

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出版当年[2019]版:
大类 | 3 区 医学
小类 | 4 区 血液学 4 区 肿瘤学
最新[2023]版:
大类 | 4 区 医学
小类 | 4 区 血液学 4 区 肿瘤学
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出版当年[2018]版:
Q3 HEMATOLOGY Q3 ONCOLOGY
最新[2023]版:
Q3 ONCOLOGY Q3 HEMATOLOGY

影响因子: 最新[2023版] 最新五年平均 出版当年[2018版] 出版当年五年平均 出版前一年[2017版] 出版后一年[2019版]

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第一作者机构: [1]Capital Med Univ, Beijing Tongren Hosp, Dept Haematol, Beijing 100730, Peoples R China
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通讯机构: [1]Capital Med Univ, Beijing Tongren Hosp, Dept Haematol, Beijing 100730, Peoples R China [2]Beihang Univ, Beijing Adv Innovat Ctr Big Data Based Precis Med, Beijing, Peoples R China [3]Capital Med Univ, Beijing Tongren Hosp, Beijing, Peoples R China [*1]Department of Haematology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China
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