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Comparative analysis of clinicopathologic characteristics and prognosis between nasal and nonnasal extranodal NK/T-cell lymphoma

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机构: [1]Anhui Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Hefei, Anhui, Peoples R China [2]Xuzhou Med Univ, Dept Hematol, Affiliated Hosp, Xuzhou, Jiangsu, Peoples R China [3]First Peoples Hosp Huaian, Dept Hematol, Huaian, Jiangsu, Peoples R China [4]Jining Med Univ, Dept Hematol, Affiliated Hosp, Jining, Shandong, Peoples R China [5]Shandong Univ, Dept Hematol, Qilu Hosp, Jinan 250012, Shandong, Peoples R China [6]Taian Cent Hosp, Dept Hematol, Tai An, Shandong, Peoples R China [7]Gen Hosp Wanbei Coal Elect Grp, Dept Hematol, Suzhou, Anhui, Peoples R China [8]Yancheng First Peoples Hosp, Dept Hematol, Yancheng, Jiangsu, Peoples R China [9]Zhengzhou Univ, Dept Hematol, Affiliated Hosp 1, Zhengzhou, Henan, Peoples R China [10]Capital Med Univ, Beijing Tongren Hosp, Dept Hematol, Beijing, Peoples R China [11]Xuzhou Med Univ, Blood Dis Inst, Xuzhou, Jiangsu, Peoples R China [12]Key Lab Bone Marrow Stem Cell, Xuzhou, Jiangsu, Peoples R China [13]Xuzhou Med Univ, Dept Hematol, Affiliated Hosp, Xuzhou 221006, Jiangsu, Peoples R China
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关键词: clinicopathologic extranodal natural killer/T-cell lymphoma nasal nonnasal

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BackgroundThe clinicopathologic characteristics and prognosis of nasal and nonnasal extranodal natural killer T-cell lymphoma (ENKTL) are considered to be different. However, the underlying features responsible for these differences are not well clarified especially in the era of asparaginase therapy.MethodsIn total, 1007 newly diagnosed ENKTL patients from 11 medical centers were included in this study. Clinicopathologic characteristics and survival data were collected. The chi-squared test and Kruskal-Wallis test were utilized for the comparison of different groups. Univariable and multivariable Cox proportional hazards models were used to screen prognostic factors.ResultsOverall, 869 (86.3%) patients were nasal forms. Compared to patients with nasal ENKTL, nonnasal patients were at more advanced stages and had poor performance status, bone marrow involvement, elevated serum lactate dehydrogenase (LDH), and CD56-negative status (p < 0.05). The 5-year overall survival (OS) for nasal and nonnasal patients were 65.6% and 45.0%, respectively. The OS of nasal forms patients were superior to nonnasal patients, especially in Eastern Cooperative Oncology Group performance status (ECOG PS) (>= 2), advanced stage, KPI (HIR/HR), IPI (HIR/HR), PINK (HR), and high EBV DNA load groups. In patients treated with pegaspargase/L-asparaginase-based regimens, the OS of nasal patients was better than that of nonnasal patients. After adjusting the covariates of age, stage, ECOG PS score, LDH, B symptoms, and BM involvement, results showed that the nonnasal site was associated with poor survival of ENKTL.ConclusionsThe clinicopathologic characteristics and prognosis of nasal and nonnasal ENKTL patients are different. Nasal forms patients had superior OS than nonnasal patients, especially in the era of asparaginase.

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出版当年[2022]版:
大类 | 3 区 医学
小类 | 3 区 肿瘤学
最新[2023]版:
大类 | 2 区 医学
小类 | 3 区 肿瘤学
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出版当年[2021]版:
Q2 ONCOLOGY
最新[2023]版:
Q2 ONCOLOGY

影响因子: 最新[2023版] 最新五年平均 出版当年[2021版] 出版当年五年平均 出版前一年[2020版] 出版后一年[2022版]

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第一作者机构: [1]Anhui Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Hefei, Anhui, Peoples R China
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通讯机构: [2]Xuzhou Med Univ, Dept Hematol, Affiliated Hosp, Xuzhou, Jiangsu, Peoples R China [11]Xuzhou Med Univ, Blood Dis Inst, Xuzhou, Jiangsu, Peoples R China [12]Key Lab Bone Marrow Stem Cell, Xuzhou, Jiangsu, Peoples R China [13]Xuzhou Med Univ, Dept Hematol, Affiliated Hosp, Xuzhou 221006, Jiangsu, Peoples R China
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