BackgroundThe clinicopathologic characteristics and prognosis of nasal and nonnasal extranodal natural killer T-cell lymphoma (ENKTL) are considered to be different. However, the underlying features responsible for these differences are not well clarified especially in the era of asparaginase therapy.MethodsIn total, 1007 newly diagnosed ENKTL patients from 11 medical centers were included in this study. Clinicopathologic characteristics and survival data were collected. The chi-squared test and Kruskal-Wallis test were utilized for the comparison of different groups. Univariable and multivariable Cox proportional hazards models were used to screen prognostic factors.ResultsOverall, 869 (86.3%) patients were nasal forms. Compared to patients with nasal ENKTL, nonnasal patients were at more advanced stages and had poor performance status, bone marrow involvement, elevated serum lactate dehydrogenase (LDH), and CD56-negative status (p < 0.05). The 5-year overall survival (OS) for nasal and nonnasal patients were 65.6% and 45.0%, respectively. The OS of nasal forms patients were superior to nonnasal patients, especially in Eastern Cooperative Oncology Group performance status (ECOG PS) (>= 2), advanced stage, KPI (HIR/HR), IPI (HIR/HR), PINK (HR), and high EBV DNA load groups. In patients treated with pegaspargase/L-asparaginase-based regimens, the OS of nasal patients was better than that of nonnasal patients. After adjusting the covariates of age, stage, ECOG PS score, LDH, B symptoms, and BM involvement, results showed that the nonnasal site was associated with poor survival of ENKTL.ConclusionsThe clinicopathologic characteristics and prognosis of nasal and nonnasal ENKTL patients are different. Nasal forms patients had superior OS than nonnasal patients, especially in the era of asparaginase.
基金:
This study was funded by the Natural Science Foundation
of Jiangsu Province, Grant/Award Number BK20171181;
Jiangsu Key Research and Development Project of Social
Development, Grant/Award Number BE2019638; and
Young Medical Talents of Jiangsu Science and Education
Health Project, Grant/Award Number QNRC2016791.
第一作者机构:[1]Anhui Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Hefei, Anhui, Peoples R China
共同第一作者:
通讯作者:
通讯机构:[2]Xuzhou Med Univ, Dept Hematol, Affiliated Hosp, Xuzhou, Jiangsu, Peoples R China[11]Xuzhou Med Univ, Blood Dis Inst, Xuzhou, Jiangsu, Peoples R China[12]Key Lab Bone Marrow Stem Cell, Xuzhou, Jiangsu, Peoples R China[13]Xuzhou Med Univ, Dept Hematol, Affiliated Hosp, Xuzhou 221006, Jiangsu, Peoples R China
推荐引用方式(GB/T 7714):
Shen Ziyuan,Chen Xicheng,Sun Cai,et al.Comparative analysis of clinicopathologic characteristics and prognosis between nasal and nonnasal extranodal NK/T-cell lymphoma[J].CANCER MEDICINE.2023,12(23):21138-21147.doi:10.1002/cam4.6674.
APA:
Shen, Ziyuan,Chen, Xicheng,Sun, Cai,Lu, Tianyi,Shi, Yuye...&Sang, Wei.(2023).Comparative analysis of clinicopathologic characteristics and prognosis between nasal and nonnasal extranodal NK/T-cell lymphoma.CANCER MEDICINE,12,(23)
MLA:
Shen, Ziyuan,et al."Comparative analysis of clinicopathologic characteristics and prognosis between nasal and nonnasal extranodal NK/T-cell lymphoma".CANCER MEDICINE 12..23(2023):21138-21147