Circular RNAs (circRNAs) are highly conserved and stable closed-loop non-coding RNAs. They are involved in numerous biological functions, including regulating gene transcription or protein translation by interacting with proteins and regulating expression of microRNAs. The aberrant expression of circRNAs has been reported in many cancers, including gastric cancer. By regulating gene expression, circRNAs are able to affect the proliferation, invasion and metastasis of gastric cancer. The current review focused on the characteristics and biological functions of circRNAs, the carcinogenic potential and the possible implications of circRNAs on the diagnosis and treatment of gastric cancer. In conclusion, circRNAs may serve as potential biomarkers for diagnosis, as well as therapeutic targets.
基金：
Shanghai Tongren Hospital [2019shtrxx09]; Project of Shanghai Municipal Commission of Health and Family Planning [20174Y0231]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81672335]; Shanghai Jiaotong University, Medical Professionals Cross Fund [YG2016ZD10]; SJTU Research Project Grants 2019, University of Sydney, Australia
第一作者机构：[1]Shanghai Jiao Tong Univ, Tongren Hosp, Dept Oncol, Sch Med, 1111 Xianxia Rd, Shanghai 200336, Peoples R China[2]Beihua Univ, Dept Clin Lab Diagnost, Jilin 132012, Jilin, Peoples R China
共同第一作者：
通讯作者：
通讯机构：[1]Shanghai Jiao Tong Univ, Tongren Hosp, Dept Oncol, Sch Med, 1111 Xianxia Rd, Shanghai 200336, Peoples R China[3]Univ Sydney, Sch Med Sci, Charles Perkins Ctr, Discipline Pathol, Johns Hopkins Dr, Sydney, NSW 2006, Australia[4]Univ Sydney, Bosch Inst, Charles Perkins Ctr, Discipline Pathol, Johns Hopkins Dr, Sydney, NSW 2006, Australia[*1]Department of Oncology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, 1111 Xianxia Road, Shanghai 200336, P.R. China[*2]Discipline of Pathology, School of Medical Science and Bosch Institute, Charles Perkins Centre, The University of Sydney, Johns Hopkins Drive, Camperdown, Sydney, NSW 2006, Australia
推荐引用方式(GB/T 7714)：
Yang Chun-Mei,Qiao Guang-Lei,Song Li-Na,et al.Circular RNAs in gastric cancer: Biomarkers for early diagnosis[J].ONCOLOGY LETTERS.2020,20(1):465-473.doi:10.3892/ol.2020.11623.
APA：
Yang, Chun-Mei,Qiao, Guang-Lei,Song, Li-Na,Bao, Shisan&Ma, Li-Jun.(2020).Circular RNAs in gastric cancer: Biomarkers for early diagnosis.ONCOLOGY LETTERS,20,(1)
MLA：
Yang, Chun-Mei,et al."Circular RNAs in gastric cancer: Biomarkers for early diagnosis".ONCOLOGY LETTERS 20..1(2020):465-473
