机构:[1]Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, No 1, Dongjiaominxiang Street, Dongcheng District, Beijing 100730, China首都医科大学附属北京同仁医院临床科室眼科眼底科[2]Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China首都医科大学附属同仁医院[3]Casey Eye Institute, Oregon Health & Science University, Portland, OR, USA
Purpose To explore the evolution of outer foveolar lucency (OFL) after vitrectomy and the correlation between OFL and visual acuity (VA) outcome in eyes with large idiopathic macular hole (IMH). Methods In this retrospective study, 244 eyes of 233 subjects with large IMH (diameter > 400 mu m), who underwent vitrectomy, were included. Preoperative clinical data, postoperative optical coherence tomography (OCT) images, and VA at 1-, 4-, and 10-month visits were documented. The prevalence, incidence, and width of OFL and their correlation with postoperative VA were analyzed. Results The prevalence of OFL was 10.4% (24/231) at 1 month and significantly increased to 30.4% (55/181) at 4 months (P < 0.001) and 34.2% (25/73) at 10 months (P < 0.001). The incidence was 26.1% (40/153) and 22.0% (9/41) at 4 and 10 months, respectively. OFL appeared at 1 month while disappeared at 4 or 10 months in 8 eyes (50.0%). The presence of OFL at 1 month was negatively associated with IMH diameter (NagelkerkeR(2) = 0.06;P = 0.02). Eyes with OFL at 4 months had better VA at their 4-month visit than eyes without OFL (P = 0.02). Eyes with early-developed OFLs had better VA at 10 months than those with later-developed ones (P = 0.02). Width of OFL was not associated with postoperative VA at any point. Conclusions OFL is not rare in eyes with large IMH after surgery. It can occur gradually and remain during the 10-month follow-up. The presence of OFL appears to have no negative impact on the postoperative VA and it may represent the remodeling of foveal photoreceptors.
第一作者机构:[1]Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, No 1, Dongjiaominxiang Street, Dongcheng District, Beijing 100730, China[2]Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China
通讯作者:
通讯机构:[1]Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, No 1, Dongjiaominxiang Street, Dongcheng District, Beijing 100730, China[2]Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China
推荐引用方式(GB/T 7714):
Qi Biying,Yu Yanping,You Qisheng,et al.Evolution and visual outcomes of outer foveolar lucency after surgery for large idiopathic macular hole[J].GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY.2020,258(10):2117-2124.doi:10.1007/s00417-020-04814-5.
APA:
Qi, Biying,Yu, Yanping,You, Qisheng,Wang, Zengyi,Wang, Jing...&Liu, Wu.(2020).Evolution and visual outcomes of outer foveolar lucency after surgery for large idiopathic macular hole.GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY,258,(10)
MLA:
Qi, Biying,et al."Evolution and visual outcomes of outer foveolar lucency after surgery for large idiopathic macular hole".GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY 258..10(2020):2117-2124