A New Co(II)-Based Coordination Polymer for Photocatalytic Degradation of Organic Dyes and Protective Effect on Spinal Cord Injury by Increasing trka Receptor Gene Expression on the NSCs
By using a light-harvesting organic ligand tris(4-(1H-imidazol-1-yl)phenyl)amine (TIPA), a new Co(II)-based coordination polymer (1) with the chemical formula of [Co-2(TIPA)(2)(Tz)][Co(TIPA)(NO3)(H2O)]center dot 4NO(3)center dot 2DMA center dot 2H(2)O has been generated via reaction of Co(NO3)(2)center dot 6H(2)O with the tetrazole (Tz) ligands and TIPA in water and DMA mixed solvent under the conditions of solvothermal. Significantly, complex 1 is capable of photodegradation of the organic dyes with the existence of hydrogen peroxide and ultraviolet irradiation (lambda = 254 nm). Furthermore, the mechanism of photocatalytic degradation of the organic dyes is studied. In biological research, we aimed to develop the compound which could increase the protective effect of NGF on NSCs during the treatment of spinal cord injury. The RT-PCR was performed to evaluate the trka receptor gene expression on the NSCs. The western was used to evaluate the activation for signaling pathway of PI3K/Akt in NSCs after compound treatment.
基金：
Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities [2042017kf0139]; Innovative Seed Funds of Medical College of Wuhan University [TFZZ2018027]; Natural Science Foundation of Hubei ProvinceNatural Science Foundation of Hubei Province [2019CFB457]; Wuhan Medical Research Project (Youth Project) [WZ19Q02]
第一作者机构：[1]Wuhan Univ, Dept Orthoped, Renmin Hosp, Wuhan, Hubei, Peoples R China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Deng Ming,Xue Jinju,Xie Ping,et al.A New Co(II)-Based Coordination Polymer for Photocatalytic Degradation of Organic Dyes and Protective Effect on Spinal Cord Injury by Increasing trka Receptor Gene Expression on the NSCs[J].JOURNAL OF INORGANIC AND ORGANOMETALLIC POLYMERS AND MATERIALS.2020,30(8):3213-3220.doi:10.1007/s10904-020-01480-2.
APA：
Deng, Ming,Xue, Jinju,Xie, Ping,Huang, Hui,Liu, Jun-Qi...&Ma, Yong-Gang.(2020).A New Co(II)-Based Coordination Polymer for Photocatalytic Degradation of Organic Dyes and Protective Effect on Spinal Cord Injury by Increasing trka Receptor Gene Expression on the NSCs.JOURNAL OF INORGANIC AND ORGANOMETALLIC POLYMERS AND MATERIALS,30,(8)
MLA：
Deng, Ming,et al."A New Co(II)-Based Coordination Polymer for Photocatalytic Degradation of Organic Dyes and Protective Effect on Spinal Cord Injury by Increasing trka Receptor Gene Expression on the NSCs".JOURNAL OF INORGANIC AND ORGANOMETALLIC POLYMERS AND MATERIALS 30..8(2020):3213-3220
