Pathological changes from the originating to the peripheral sites of Sinonasal Inverted Papilloma are the underlying mechanisms of preoperative MRI-tumor origin prediction
Background: Our previous study showed that convoluted cerebriform pattern (CCP)-based reverse tracing method in preoperative magnetic resonance imaging (MRI) is a reliable tool in predicting originating site of sinonasal inverted papilloma (SNIP).This study aimed to determine the underlying pathological mechanism of the preoperative MRI-CCP reverse tracing method by assessing the histopathological changes from the origin to the peripheral sites of SNIP. Methodology: The originating site of SNIP was predicted by preoperative MRI in 30 consecutive patients suspected to have primary SNIP. Samples of SNIP originating and peripheral sites were processed by pathological staining for evaluation of stroma score, micro-vessel density (MVD), and tight junction proteins (claudin-5, zonula occludens (ZO)-1 and occludin) expression. Results:The originating site of SNIP was accurately predicted by preoperative MRI in all patients. Stroma scores, and MVD were significantly greater in the periphery of SNIP than in the originating site. In contrast, Claudin-5 expression in micro-vessels was greater at the originating site than the periphery. Conclusions: More edematous stroma and intensive micro-vessels with defective tight junction in periphery of SNIP result in more contrast agent diffusing and CCP that can only be observed at the periphery of SNIP on T2 and contrast-enhanced T1 weighted MR images,which may be the mechanisms underlying the CCP reverse tracing method.
基金：
National Key R&D Program of China (2016YFC20160905200); national natural science foundation of China (81630023, 81400444, 81371104, 81470678 and 81420108009); program for Changjiang Scholars and Innovative Research Team (IRT13082); Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support (ZYLX201310); Beijing Natural Science Foundation (Z141107002514122); Capital Health Development Foundation (2016-1-2052) and Beijing Talents Project (2016).
第一作者机构：[1]Capital Med Univ, Beijing TongRen Hosp, Dept Otolaryngol Head & Neck Surg, Beijing, Peoples R China
共同第一作者：
通讯作者：
通讯机构：[1]Capital Med Univ, Beijing TongRen Hosp, Dept Otolaryngol Head & Neck Surg, Beijing, Peoples R China[2]Capital Med Univ, Beijing TongRen Hosp, Dept Radiol, Beijing, Peoples R China[5]Capital Med Univ, Beijing TongRen Hosp, Dept Allergy, Beijing, Peoples R China[*1]No. 1, DongJiaoMinXian Street DongCheng District Beijing, 100730 China
推荐引用方式(GB/T 7714)：
Ma Siyuan,Xian Mu,Yang Bentao,et al.Pathological changes from the originating to the peripheral sites of Sinonasal Inverted Papilloma are the underlying mechanisms of preoperative MRI-tumor origin prediction[J].RHINOLOGY.2020,58(1):59-65.doi:10.4193/Rhin19.131.
APA：
Ma, Siyuan,Xian, Mu,Yang, Bentao,Fang, Gaoli,Lou, Hongfei...&Wang, Chengshuo.(2020).Pathological changes from the originating to the peripheral sites of Sinonasal Inverted Papilloma are the underlying mechanisms of preoperative MRI-tumor origin prediction.RHINOLOGY,58,(1)
MLA：
Ma, Siyuan,et al."Pathological changes from the originating to the peripheral sites of Sinonasal Inverted Papilloma are the underlying mechanisms of preoperative MRI-tumor origin prediction".RHINOLOGY 58..1(2020):59-65
医学