机构：[1]Department of Otolaryngology Head and Neck Surgery, Beijing TongRenHospital, Capital Medical University, Beijing 100730, People’s Republic of China首都医科大学附属同仁医院[2]Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology,No.17, HouGouHuTong, DongCheng District, Beijing 100005, People’sRepublic of China首都医科大学附属北京同仁医院研究所耳鼻咽喉科研究所[3]Department of Allergy, Beijing TongRen Hospital, CapitalMedical University, Beijing 100730, People’s Republic of China临床科室变态反应科首都医科大学附属北京同仁医院首都医科大学附属同仁医院
Background Allergic rhinitis (AR) is believed to be a complex genetic disease. The last decade has been marked by the publication of more than 20 genome-wide association studies (GWASs) of AR and associated allergic phenotypes and allergic diseases, which have shown allergic diseases and traits to share a large number of genetic susceptibility loci. The aim of present study was therefore to investigate the highly replicated allergy related genes and variants as candidates for AR in Han Chinese subjects. Methods A total of 762 AR patients and 760 control subjects were recruited, and a total of 58 susceptible variants previously reported to be associated with allergic traits were choose for replication. Results Logistic regression analyses revealed that in the co-dominant-effect model as assessed by the AIC, compared with wild-type carriers, significant AR risk were associated with rs9865818 in LPP (P = 0.029, OR = 1.469 for GG vs. AA); rs6554809 in DNAH5 (P = 0.000, OR = 1.597 for TC vs. CC); rs1438673 in WDR36-CAMK4 loci (P = 0.037, OR = 1.396 for CC vs.TT), rs7775228 in HLA region (P = 0.000, OR = 1.589 for TC vs.TT), rs7203459 in CLEC16A (P = 0.025, OR = 0.731 for TC vs. TT). Conclusion We replicated Han Chinese AR-specific susceptibility loci in LPP, DNAH5, HLA, CLEC16A and WDR36-CAMK4. Further understanding the molecular mechanisms underlying these associations may provide new insights into the etiology of allergic disease.
基金：
National Key R&D Program of China (2016YFC20160905200), the national
natural science foundation of China (81570895, 81970849) and Beijing Natural
Science Foundation (7182034) to LZ, YZ and JL.
第一作者机构：[1]Department of Otolaryngology Head and Neck Surgery, Beijing TongRenHospital, Capital Medical University, Beijing 100730, People’s Republic of China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Otolaryngology Head and Neck Surgery, Beijing TongRenHospital, Capital Medical University, Beijing 100730, People’s Republic of China[2]Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology,No.17, HouGouHuTong, DongCheng District, Beijing 100005, People’sRepublic of China[3]Department of Allergy, Beijing TongRen Hospital, CapitalMedical University, Beijing 100730, People’s Republic of China
推荐引用方式(GB/T 7714)：
Gao Yunbo,Li Jingyun,Zhang Yuan,et al.Replication study of susceptibility variants associated with allergic rhinitis and allergy in Han Chinese[J].ALLERGY ASTHMA AND CLINICAL IMMUNOLOGY.2020,16(1):doi:10.1186/s13223-020-0411-9.
APA：
Gao, Yunbo,Li, Jingyun,Zhang, Yuan&Zhang, Luo.(2020).Replication study of susceptibility variants associated with allergic rhinitis and allergy in Han Chinese.ALLERGY ASTHMA AND CLINICAL IMMUNOLOGY,16,(1)
MLA：
Gao, Yunbo,et al."Replication study of susceptibility variants associated with allergic rhinitis and allergy in Han Chinese".ALLERGY ASTHMA AND CLINICAL IMMUNOLOGY 16..1(2020)
