机构：[1]Department of Otolaryngology–Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China首都医科大学附属北京同仁医院临床科室耳鼻咽喉-头颈外科[2]Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing, China首都医科大学附属北京同仁医院研究所耳鼻咽喉科研究所[3]Department of Allergy, Beijing TongRen Hospital, Capital Medical University, Beijing, China临床科室变态反应科首都医科大学附属北京同仁医院首都医科大学附属同仁医院
Background: Allergic rhinitis (AR) is a complex chronic inflammatory disease of the nasal mucosa, caused by an interaction between genetic and environmental factors. As evidence suggests that some genetic variants may increase susceptibility to both AR and asthma, the objective of this study was to identify asthma susceptibility variants associated with AR in the Chinese population. Methods: A cohort of 402 individuals with physician-diagnosed AR and 416 healthy controls were recruited from the Han Chinese population in Beijing. DNA was extracted from the peripheral blood and a total of 12 single-nucleotide polymorphisms (SNPs) shown to be associated with asthma in Japanese subjects were selected for genotyping using the SequenomMassARRAY technology platform. Results: Analysis of frequency differences of allele between the AR patients and control subjects showed that the C allele of rs204993 in the pre-B-cell leukemia homeobox 2 (PBX2) gene from the 6p21.3 locus was significantly associated with AR (p = 0.0006, p(corrected) = 0.0340). Genotype analysis further confirmed the difference in distribution of this variant between AR patients and controls in the both the dominant (p(T/C+C/C vs T/T) = 7.37x10(-5)) and co-dominant (p(T/C vs T/T) = 1.98 x 10(-4), p(C/C vs T/T) = 0.004) models. Conclusion: These results suggest that the PBX2 gene in the 6p21.3 asthma susceptibility locus may be associated with increased risk for both AR and asthma in Chinese subjects. (C) 2016 ARS-AAOA, LLC.
基金：
Funding sources for the study: Program for Changjiang Scholars and
Innovative Research Team (IRT13082); National Science Fund for the Major
International Joint Research Program (81420108009); Beijing Natural Science
Foundation (7131006); 12th five year science and technology support
program (2014BAI07B04); Beijing Municipal Administration of Hospitals
Clinical Medicine Development of Special Funding Support (ZYLX201310);
Beijing Health Bureau Program for High Level Talents (2014-3-015); Beijing
Municipal Administration of Hospitals’ Mission Plan (SML20150203).
第一作者机构：[1]Department of Otolaryngology–Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China[2]Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Otolaryngology–Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China[2]Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing, China[3]Department of Allergy, Beijing TongRen Hospital, Capital Medical University, Beijing, China[*1]Beijing Institute of Otolaryngology, No. 17, HouGouHuTong, DongCheng District, Beijing 100005, China
推荐引用方式(GB/T 7714)：
Zhao Yali,Zhang Yuan,Zhang Luo.Variant of PBX2 gene in the 6p21.3 asthma susceptibility locus is associated with allergic rhinitis in Chinese subjects[J].INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY.2016,6(5):537-543.doi:10.1002/alr.21725.
APA：
Zhao, Yali,Zhang, Yuan&Zhang, Luo.(2016).Variant of PBX2 gene in the 6p21.3 asthma susceptibility locus is associated with allergic rhinitis in Chinese subjects.INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY,6,(5)
MLA：
Zhao, Yali,et al."Variant of PBX2 gene in the 6p21.3 asthma susceptibility locus is associated with allergic rhinitis in Chinese subjects".INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY 6..5(2016):537-543
