机构：[1]Department of Otolaryngology, Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China临床科室耳鼻咽喉-头颈外科首都医科大学附属北京同仁医院首都医科大学附属同仁医院[2]Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing, China研究所耳鼻咽喉科研究所首都医科大学附属北京同仁医院首都医科大学附属同仁医院[3]Department of Allergy, Beijing TongRen Hospital, Capital Medical University, Beijing, China临床科室变态反应科首都医科大学附属北京同仁医院首都医科大学附属同仁医院
Introduction: Chronic rhinosinusitis with nasal polyps (CRSwNP) is an inflammatory airway disease characterized as tight junction loosening, inflammation, and mucosal remodeling. Epithelial cells form a barrier against allergens, bacteria, and proteases, and can also trigger or enhance the immune response by releasing various inflammatory mediators including cytokines, chemokines, and secreted proteins to promote the pathogenesis of CRSwNP. Areas covered: We review the epithelium-derived cytokine and secreted protein networks driving CRSwNP, and discuss these mediators in a cellular context. We illustrate their roles as potential mediators-biomarkers in clinical practice, which may help to understand the mechanisms underlying the pathologies of different endotypes of CRSwNP and to improve treatment outcomes in patients with CRSwNP based on the development of novel predictors for CRSwNP management. Expert opinion: The understanding of the role of epithelium-derived inflammatory mediators helps to investigate the pathophysiological mechanisms of CRSwNP endotypes. An increasing number of studies show that these mediators target immune cells and promote the recruitment, activation or regulation of the proliferation or apoptosis of these cells. Based on this achievement, further investigations are necessary to explore the multi-dimensional role of epithelium-derived inflammatory mediators in CRSwNP.
基金：
Beijing Advanced Innovation
Center for Food Nutrition and Human Health [Beijing Technology and
Business University (BTBU) 20181045]; The Program for Changjiang
Scholars and Innovative Research Team [IRT13082]; National Key R&D
Program of China [2018YFC0116800]; National Key R&D Program of
China [2016YFC20160905200]; National Science and Technology
Infrastructure Program of China during the 12th Five-Year Plan Period
[2014BAI07B04]; National Natural Science Foundation of China
[81420108009; 81630023; 81570895; 81870698 and 81400444]; Research
of Capital Health Security and Cultivation [Z18110700160000]; Beijing
Municipal Administration of Hospitals’ Mission Plan [SML20150203];
Beijing Municipal Administration of Hospitals’ Innovation Program of
Clinical Techniques [XMLX201816]; Beijing Hundred-Thousand-Ten
Thousand Founding Program [2018A10]; Beijing Municipal
Administration of Hospitals’ Youth Programme [QML20150202].
第一作者机构：[1]Department of Otolaryngology, Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China
通讯作者：
通讯机构：[1]Department of Otolaryngology, Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China[2]Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing, China[3]Department of Allergy, Beijing TongRen Hospital, Capital Medical University, Beijing, China[*1]Beijing TongRen Hospital, Capital Medical University, No. 1, DongJiaoMinXiang, DongCheng District, Beijing, China[*2]Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing 100005, China
推荐引用方式(GB/T 7714)：
Wang Chengshuo,Yan Bing,Zhang Luo.The epithelium-derived inflammatory mediators of chronic rhinosinusitis with nasal polyps[J].EXPERT REVIEW OF CLINICAL IMMUNOLOGY.2020,16(3):293-310.doi:10.1080/1744666X.2020.1723417.
APA：
Wang, Chengshuo,Yan, Bing&Zhang, Luo.(2020).The epithelium-derived inflammatory mediators of chronic rhinosinusitis with nasal polyps.EXPERT REVIEW OF CLINICAL IMMUNOLOGY,16,(3)
MLA：
Wang, Chengshuo,et al."The epithelium-derived inflammatory mediators of chronic rhinosinusitis with nasal polyps".EXPERT REVIEW OF CLINICAL IMMUNOLOGY 16..3(2020):293-310
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