Objective Populations in different countries and regions have different characteristics of cardiovascular risk factors. Grasping these characteristics and developing targeted prevention and management strategies are essential to prevent cardiovascular diseases (CVD). So we conducted this study to investigate the prevalence of overweight/obesity and metabolic abnormalities of adults in eastern China. Methods We collected data of 103,183 adults who received routine physical examination. Compared the prevalence of overweight/obesity, metabolic indicators, and the proportion of metabolic abnormalities in different age and gender subgroups. Results Compared with other age and gender subgroups, middle-aged male had a significantly higher prevalence of general and abdominal overweight/obesity (48.8%/15.1% and 43%/13.3%, respectively). In addition, the prevalence of high DBP, hyperuricemia, high TC, TG, LDL, Non-HDLc, and low HDL-C were 24.6%, 15.8%, 34.5%, 45.1%, 19.4%, 23.6%, and 36.7%, respectively in midlife male. Conclusions Middle-aged male had higher level of CVD risk in eastern China. Government, individuals, and health care professionals should develop targeted age and gender-based intervention to prevent weight gain and manage metabolic abnormalities.