Effects of Balanced Ultrafiltration During Extracorporeal Circulation for Children with Congenital Heart Disease on Postoperative Serum Inflammatory Response
机构：[1]Department of Cardiovascular Surgery, Children’s Hospital of Nanjing Medical University, Nanjing, China[2]Outpatient Department, Nanjing Tongren Hospital, School of Medicine, Southeast University, Nanjing, China
Objectives: We studied inflammatory marker changes with ultrafiltration extracorporeal techniques and compared these levels to those occurring during conventional techniques. Methods: Seventy-four children undergoing extracorporeal circulation during congenital heart surgery were divided into two groups-conventional (control) and balanced ultrafiltrations (study). Serum interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and soluble intercellular adhesion molecule-1 (sICAM-1), static lung compliance (Cstat), alveolar-arterial oxygen partial pressure difference (A-aDO2), and oxygenation index (OI) were measured. Results: Thirty minutes after extracorporeal circulation (T1), IL-6 and TNF-alpha levels significantly increased (p < .05), which plummeted 3 h after surgery (T2). The levels in the study group were lower (p < .05). sICAM-1 levels at T1 and T2 significantly exceeded those at T0, and study group had lower levels (p < .05). At T1, Cstat and OI dropped (p < .05), which increased at T2 (p < .05), and study group had less decreases (p < .05). A-aDO2 at T1 surpassed that before intervention (p < .05), and study group had less increase (p < .05). Conclusion: Balanced ultrafiltration exerts protective effects on children with congenital heart disease undergoing extracorporeal circulation.
第一作者机构：[1]Department of Cardiovascular Surgery, Children’s Hospital of Nanjing Medical University, Nanjing, China
通讯作者：
通讯机构：[1]Department of Cardiovascular Surgery, Children’s Hospital of Nanjing Medical University, Nanjing, China[*1]Department of Cardiovascular Surgery, Children’s Hospital of Nanjing Medical University, No. 72 Guangzhou Road, Nanjing, China.
推荐引用方式(GB/T 7714)：
Chen Feng,You Yunpeng,Ding Peicheng,et al.Effects of Balanced Ultrafiltration During Extracorporeal Circulation for Children with Congenital Heart Disease on Postoperative Serum Inflammatory Response[J].FETAL AND PEDIATRIC PATHOLOGY.2020,39(5):401-408.doi:10.1080/15513815.2019.1661050.
APA：
Chen, Feng,You, Yunpeng,Ding, Peicheng,Wu, Kaihong&Mo, Xuming.(2020).Effects of Balanced Ultrafiltration During Extracorporeal Circulation for Children with Congenital Heart Disease on Postoperative Serum Inflammatory Response.FETAL AND PEDIATRIC PATHOLOGY,39,(5)
MLA：
Chen, Feng,et al."Effects of Balanced Ultrafiltration During Extracorporeal Circulation for Children with Congenital Heart Disease on Postoperative Serum Inflammatory Response".FETAL AND PEDIATRIC PATHOLOGY 39..5(2020):401-408
