机构：[1]Capital Med Univ, Beijing Tongren Hosp, Dept Otorhinolaryngol Head & Neck Surg, 1 Dong Jiao Min Xiang, Beijing 100730, Peoples R China临床科室耳鼻咽喉-头颈外科首都医科大学附属北京同仁医院首都医科大学附属同仁医院[2]Inner Mongolia Med Univ, Dept Otorhinolaryngol, Affiliated Hosp, Hohhot, Peoples R China
Traditional Chinese Medicine (TCM) has been considered to provide certain advantages in the treatment of cancer. Guben Yiliu II (GY II) has been widely used for clinical treatment of cancer in China. The current study investigated the effects of GY II on proliferation, apoptosis, invasion, and metastasis of laryngeal squamous cell carcinoma via MTT assays, Transwell assays, and flow cytometry, respectively, in Hep-2 and cells from clinical samples. Results of MTT assays revealed that GY II inhibited the growth of cells via arresting the cell cycle at G0/G1 phase. The addition of GY II significantly suppressed cell migration and invasion. Additionally, GY II treatment significantly promoted apoptosis of tumor cells. Present findings have significant implications regarding the understanding of mechanisms and targets of GY II in terms of tumors.
基金：
National Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81473499]
第一作者机构：[1]Capital Med Univ, Beijing Tongren Hosp, Dept Otorhinolaryngol Head & Neck Surg, 1 Dong Jiao Min Xiang, Beijing 100730, Peoples R China[2]Inner Mongolia Med Univ, Dept Otorhinolaryngol, Affiliated Hosp, Hohhot, Peoples R China
通讯作者：
通讯机构：[1]Capital Med Univ, Beijing Tongren Hosp, Dept Otorhinolaryngol Head & Neck Surg, 1 Dong Jiao Min Xiang, Beijing 100730, Peoples R China[*1]Depart-ment of Otorhinolaryngology Head and Neck Sur-gery, Beijing Tongren Hospital, Capital Medical University, No.1 Dong Jiao Min Xiang, Eastern Dis-trict, Beijing 100730, China.
推荐引用方式(GB/T 7714)：
Bai Yunfei,Wang Ru,Cui Xiaobo,et al.GY II represses proliferation and metastasis and promotes apoptosis in laryngeal squamous cell carcinoma[J].INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE.2019,12(8):9935-9943.
APA：
Bai, Yunfei,Wang, Ru,Cui, Xiaobo,Feng, Lin,Shi, Qian...&Fang, Jugao.(2019).GY II represses proliferation and metastasis and promotes apoptosis in laryngeal squamous cell carcinoma.INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE,12,(8)
MLA：
Bai, Yunfei,et al."GY II represses proliferation and metastasis and promotes apoptosis in laryngeal squamous cell carcinoma".INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE 12..8(2019):9935-9943
