Background: The frequency distributions of the etiologies of chronic cough have changed over time. This study aimed to investigate the changing etiological frequency of chronic cough in a tertiary hospital in Shanghai, China, and to explore the clinical significance. Methods: Medical records of 1,311 patients with chronic cough who visit our hospital between January 2009 and December 2016 were retrospectively reviewed. The etiologies of chronic cough were identified according to a standardized step-by-step diagnostic protocol and the changes in the etiological frequency of chronic cough over the years were using the Chi-squared (chi(2)) test. Results: Cough variant asthma (CVA) (449/1,311, 34.2%), gastroesophageal reflux-related chronic cough (GERC) (374/1,311, 28.5%), upper airway cough syndrome/postnasal drip syndrome (UACS/PNDs) (241/1,311, 18.4%), atopic cough (AC) (188/1,311, 14.3%), and non-asthmatic eosinophilic bronchitis (NAEB) (147/1,311, 11.2%) were the common causes of chronic cough in descending order. The post-infectious cough (PIC) (39/1,311, 3.0%) and angiotensin-converting enzyme inhibitor (ACED-induced cough (25/1,311, 1.9%) were less common. During the 8-year period, the proportion of CVA (chi(2) =72.86, P<0.0001) and UACS/PNDs (chi(2) =68.80, P<0.0001) decreased, while those of NAEB (chi(2 )=51.38, P<0.0001), GERC (chi(2) =55.95, P<0.0001) and AC (chi(2) =39.09, P<0.0001) increased. Conclusions: The etiological frequency of chronic cough varies over time, and it may encourage the adjustment of the current diagnostic and therapeutic strategies for chronic cough.
基金：
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81770097, 81670092]; Project of Science and Technology Commission of Shanghai MunicipalityScience & Technology Commission of Shanghai Municipality (STCSM) [17411970800]
第一作者机构：[1]Tongji Univ, Tongji Hosp, Dept Pulm & Crit Care Med, Sch Med, 389 Xincun Rd, Shanghai 200065, Peoples R China[2]Shanghai Putuo Dist Peoples Hosp, Dept Pulm & Crit Care Med, Shanghai 200060, Peoples R China
共同第一作者：
通讯作者：
通讯机构：[1]Tongji Univ, Tongji Hosp, Dept Pulm & Crit Care Med, Sch Med, 389 Xincun Rd, Shanghai 200065, Peoples R China[*1]Department of Pulmonary and Critical Care Medicine, Tongji Hospital, Tongji University School of Medicine, No. 389 Xincun Road, Shanghai 200065, China
推荐引用方式(GB/T 7714)：
Ding Hongmei,Xu Xianghuai,Wen Siwan,et al.Changing etiological frequency of chronic cough in a tertiary hospital in Shanghai, China[J].JOURNAL OF THORACIC DISEASE.2019,11(8):3482-3489.doi:10.21037/jtd.2019.07.86.
APA：
Ding, Hongmei,Xu, Xianghuai,Wen, Siwan,Yu, Yining,Pan, Jing...&Yu, Li.(2019).Changing etiological frequency of chronic cough in a tertiary hospital in Shanghai, China.JOURNAL OF THORACIC DISEASE,11,(8)
MLA：
Ding, Hongmei,et al."Changing etiological frequency of chronic cough in a tertiary hospital in Shanghai, China".JOURNAL OF THORACIC DISEASE 11..8(2019):3482-3489
