机构：[1]Department of Respiratory Medicine, Children’s Hospital of Soochow University, Suzhou 215003, China[2]Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing 100000, China临床科室耳鼻咽喉-头颈外科首都医科大学附属北京同仁医院首都医科大学附属同仁医院[3]Department of Allergy, Beijing Tongren Hospital, Capital Medical University, Beijing 100000, China临床科室变态反应科首都医科大学附属北京同仁医院首都医科大学附属同仁医院[4]Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing 100005, China研究所耳鼻咽喉科研究所首都医科大学附属北京同仁医院首都医科大学附属同仁医院
Background: Chronic cough is a common symptom in children. We wished to explore the value of fractional exhaled nitric oxide (FeNO) for cough-variant asthma (CVA) in children with chronic cough. Methods: This prospective cohort study was conducted in the Children's Hospital of Soochow University from January 2012 to December 2014. Children aged 6-14 years with a cough of duration >4 weeks were enrolled. They underwent FeNO measurement, sputum cytology and pulmonary function tests. Results: A total of 115 patients and 25 healthy controls were evaluated. For the diagnosis of CVA, the optimal FeNO cutoff value was 25 ppb with a sensitivity of 84.0%, specificity of 97.1%, positive predictive value of 97.5%, and negative predictive of being 81.4%. The FeNO level had a significant correlation with eosinophil count in sputum (P<0.05). FeNO level in CVA was decreased significantly after treatment (P=0.001). Conclusions: In children, FeNO measurement might be an excellent method for diagnosing CVA with high sensitivity and specificity.
基金：
Social Development Projects of Jiangsu Province [BE2016676]; Key Lab of Respiratory Disease of Suzhou [SZS201714]; Research Project of Provincial Health and Family Planning Commission [H201622]; Science and Technology Program of Suzhou [SYS201641, SYS201558]; Beijing Natural Science FoundationBeijing Natural Science Foundation [7164247]; Priming Scientific Research Foundation for the Junior Researcher in Beijing Tongren Hospital, Capital Medical University [2015-YJJ-ZZL-010]
第一作者机构：[1]Department of Respiratory Medicine, Children’s Hospital of Soochow University, Suzhou 215003, China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Respiratory Medicine, Children’s Hospital of Soochow University, Suzhou 215003, China[2]Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing 100000, China[3]Department of Allergy, Beijing Tongren Hospital, Capital Medical University, Beijing 100000, China[4]Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing 100005, China[*1]Department of Respiratory Medicine, Children’s Hospital of Soochow University, Suzhou 215003, China.[*2]Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing 100005, China.
推荐引用方式(GB/T 7714)：
Zhou Jing,Zhao Xianhong,Zhang Xu,et al.Values of fractional exhaled nitric oxide for cough-variant asthma in children with chronic cough[J].JOURNAL OF THORACIC DISEASE.2018,10(12):6616-6623.doi:10.21037/jtd.2018.11.137.
APA：
Zhou, Jing,Zhao, Xianhong,Zhang, Xu,Yu, Xingmei,Wang, Yuqing...&Zhang, Luo.(2018).Values of fractional exhaled nitric oxide for cough-variant asthma in children with chronic cough.JOURNAL OF THORACIC DISEASE,10,(12)
MLA：
Zhou, Jing,et al."Values of fractional exhaled nitric oxide for cough-variant asthma in children with chronic cough".JOURNAL OF THORACIC DISEASE 10..12(2018):6616-6623
