机构：[1]Institute of Nano Biomedicine and Engineering, Shanghai Engineering Center for Intelligent Diagnosis and Treatment Instrument, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai, China[2]School of Biomedical Engineering, Institute for Personalized Medicine, Shanghai Jiao Tong University, Shanghai, China[3]Institute of Refrigeration and Cryogenics, Shanghai Jiao Tong University, Shanghai, China[4]Department of Gastroenterology, Xi'an Central Hospital, Xi'an, China[5]Department of Oncology, Shanghai Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China[6]Queen Mary University London, School of Engineering & Material Science, London, England[7]School of Statistics and Management, Shanghai University of Finance and Economics Yangpu District, Shanghai,China[8]National Center for Translational Medicine, Shanghai Jiao Tong University, Shanghai, China
How to eradicate Helicobacter pylori (H. pylori) in vivo with antibiotic resistance owns tremendous clinical requirement. Herein, gold nanostars were conjugated with acid-sensitive cis-aconitic anhydride modified anti-H. pylori polyclonal antibodies, resultant pH sensitive gold nanostars@H. pylori-antibodies nanoprobes (GNS@Ab) were employed for the theranostics of H. pylori in vivo. Photoacoustic imaging confirmed that prepared GNS@Ab could target actively H. pylori in the stomach. GNS@Ab nanoprobes could kill H. pylori in vivo in model animals under NIR laser irradiation. all GNS@Ab nanoprobes could be excreted out of gut within 7 days after oral administration. Gastric local lesion caused by H. pylori restored to normal status within one month. GNS@Ab nanoprobes within therapeutic doses did not damage intestinal bacteria imbalance. Forty clinical specimens of H. pylori with antibiotic resistance were verified validity of GNS@Ab nanoprobes. Prepared oral pH-sensitive GNS@Ab nanoprobes own clinical translational potential in the theranostics of H. pylori in near future. (C) 2019 Elsevier Inc. All rights reserved.
基金：
This work supported by Key Basic Research Program of
China (No. 2017YFA0205304), Nature Scientific foundation of China (No.
81602184), Training Foundation for Young Talents of Shanghai Jiao Tong
University (No. 18X100040040), and Medical Engineering Cross Project of
Shanghai JiaoTong University (YG2016ZD10, ZH2018QNA51,ZH2018QNA28).
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2018]版：
大类|2 区医学
小类|2 区医学：研究与实验3 区纳米科技
最新[2023]版：
大类|2 区医学
小类|3 区医学：研究与实验3 区纳米科技
JCR分区：
出版当年[2017]版：
Q1NANOSCIENCE & NANOTECHNOLOGYQ1MEDICINE, RESEARCH & EXPERIMENTAL
最新[2023]版：
Q2NANOSCIENCE & NANOTECHNOLOGYQ2MEDICINE, RESEARCH & EXPERIMENTAL
第一作者机构：[1]Institute of Nano Biomedicine and Engineering, Shanghai Engineering Center for Intelligent Diagnosis and Treatment Instrument, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai, China[2]School of Biomedical Engineering, Institute for Personalized Medicine, Shanghai Jiao Tong University, Shanghai, China
通讯作者：
通讯机构：[1]Institute of Nano Biomedicine and Engineering, Shanghai Engineering Center for Intelligent Diagnosis and Treatment Instrument, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai, China[3]Institute of Refrigeration and Cryogenics, Shanghai Jiao Tong University, Shanghai, China[8]National Center for Translational Medicine, Shanghai Jiao Tong University, Shanghai, China[*1]Institute of Nano Biomedicine and Engineering, Shanghai Engineering Center for Intelligent Diagnosis and Treatment Instrument, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.
推荐引用方式(GB/T 7714)：
Zhi Xiao,Liu Yanlei,Lin Lingnan,et al.Oral pH sensitive GNS@ab nanoprobes for targeted therapy of Helicobacter pylori without disturbance gut microbiome[J].NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE.2019,20:doi:10.1016/j.nano.2019.102019.
APA：
Zhi, Xiao,Liu, Yanlei,Lin, Lingnan,Yang, Meng,Zhang, Lingxia...&Cui, Daxiang.(2019).Oral pH sensitive GNS@ab nanoprobes for targeted therapy of Helicobacter pylori without disturbance gut microbiome.NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE,20,
MLA：
Zhi, Xiao,et al."Oral pH sensitive GNS@ab nanoprobes for targeted therapy of Helicobacter pylori without disturbance gut microbiome".NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE 20.(2019)
