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Helicobacter pylori infection as a risk factor for serum bilirubin change and less favourable lipid profiles: a hospital-based health examination survey

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机构: [1]Capital Med Univ, Beijing Tongren Hosp, Beijing Diabet Inst, Dept Endocrinol, Beijing 100730, Peoples R China [2]Univ Otago, Edgar Diabet & Obes Res Ctr, Wellington, New Zealand [3]Capital Med Univ, Beijing Tongren Hosp, Phys Examinat Dept, Beijing 100730, Peoples R China [4]Capital Med Univ, Sch Biomed Engn, Dept Biostat & Bioinformat, Beijing 100069, Peoples R China [5]Univ Otago, Dunedin Sch Med, Dept Med, Dunedin, New Zealand
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关键词: Helicobacter pylori Serum bilirubin Metabolic disorders Lipid metabolism

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Helicobacter pylori infection is associated with several extragastric conditions including dyslipidemia and metabolic syndrome. This study aimed to investigate additional metabolic parameters associated with H. pylori infection in a Chinese population. Using a case-control approach we studied 617 subjects with C-13-urea breath test (C-13-UBT) values ae<yen>10aEuro degrees who were defined as being positive for H. pylori (cases), while 617 sex and age- matched subjects with C-13-UBT values ae<currency>1aEuro degrees were defined as H. pylori negative (controls) in Beijing Tongren Hospital from March 2016 to May 2017. Biochemical parameters including serum bilirubin and lipids were tested. A total of 1982 subjects participated in this study. The H. pylori infected subjects had significantly lower serum direct bilirubin concentrations (2.34 +/- 0.38 vs. 2.47 +/- 0.90 mu mol/L, P = 0.008). H. pylori infection was independently associated with lower direct bilirubin levels (OR = 1.497, 95% CI =1.121-1.999, P = 0.006) or total bilirubin levels (OR = 1.322, 95% CI =1.005-1.738, P = 0.046) after adjustment for age, sex, body mass index (BMI), alanine aminotransferase (ALT), aspartate aminotransferase (AST), high-density lipoprotein cholesterol (HDL-C), low density lipoprotein-cholesterol (LDL-C), total cholesterol (TC) and triglycerides(TG). In addition, the H. pylori infected subjects had higher LDL-C levels (2.98 +/- 0.76 vs. 2.89 +/- 0.75 mmol/L, P = 0.033) and lower HDL-C levels (1.39 +/- 0.37 vs. 1.44 +/- 0.41 mmol/L, P = 0.044). LDL-C was negatively correlated with direct bilirubin concentration (R = - 0.260, P < 0.0001). Bilirubin has been found to be a potent endogenous antioxidant and negatively associated with metabolic syndrome. Our results suggest that H. pylori infection is an independent risk factor for serum bilirubin reduction and less favorable lipid profiles.

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出版当年[2018]版:
大类 | 3 区 医学
小类 | 3 区 传染病学
最新[2023]版:
大类 | 3 区 医学
小类 | 3 区 传染病学
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出版当年[2017]版:
Q2 INFECTIOUS DISEASES
最新[2023]版:
Q2 INFECTIOUS DISEASES

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第一作者机构: [1]Capital Med Univ, Beijing Tongren Hosp, Beijing Diabet Inst, Dept Endocrinol, Beijing 100730, Peoples R China
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