Allergen immunotherapy (AIT) is the only disease-modifying treatment option for patients with IgE-mediated inhalant allergies. Though used in clinical practice for more than 100 years, most innovations in AIT efficacy and safety have been developed in the last two decades. This expert review aimed to highlight the recent progress in AIT for both application routes, the sublingual (SLIT) and subcutaneous (SCIT) forms. As such, it covers recent aspects regarding efficacy and safety in clinical trials and real-life data and outlines new concepts in consensus and position papers as well as in guidelines for AIT. Potential clinical and nonclinical biomarkers are discussed. This review also focuses on potential future perspectives in AIT, such as alternative application routes, immune-modulating adjuvants, and recombinant vaccines. In conclusion, this state of the art review provides a comprehensive overview of AIT and highlights unmet needs for the future.
第一作者机构：[1]Philipps Univ Marburg, Univ Hosp Marburg, Sect Rhinol & Allergy, Dept Otorhinolaryngol Head & Neck Surg, Marburg, Germany[*1]Department of Otorhinolaryngology, Head and Neck Surgery, Section of Rhinology and Allergy, University Hospital Marburg, Philipps- Universität Marburg, Marburg, Germany.
通讯作者：
通讯机构：[1]Philipps Univ Marburg, Univ Hosp Marburg, Sect Rhinol & Allergy, Dept Otorhinolaryngol Head & Neck Surg, Marburg, Germany[2]Capital Med Univ, Beijing TongRen Hosp, Dept Otolaryngol Head & Neck Surg, Beijing, Peoples R China[3]Beijing Inst Otolaryngol, Beijing Key Lab Nasal Dis, Beijing, Peoples R China[4]Capital Med Univ, Beijing TongRen Hosp, Dept Allergy, Beijing, Peoples R China[*1]Department of Otorhinolaryngology, Head and Neck Surgery, Section of Rhinology and Allergy, University Hospital Marburg, Philipps- Universität Marburg, Marburg, Germany.[*2]Department of Otolaryngology, Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China
推荐引用方式(GB/T 7714)：
Pfaar Oliver,Lou Hongfei,Zhang Yuan,et al.Recent developments and highlights in allergen immunotherapy[J].ALLERGY.2018,73(12):2274-2289.doi:10.1111/all.13652.
APA：
Pfaar, Oliver,Lou, Hongfei,Zhang, Yuan,Klimek, Ludger&Zhang, Luo.(2018).Recent developments and highlights in allergen immunotherapy.ALLERGY,73,(12)
MLA：
Pfaar, Oliver,et al."Recent developments and highlights in allergen immunotherapy".ALLERGY 73..12(2018):2274-2289
医学