机构:[1]Department of Otolaryngology, Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University临床科室耳鼻咽喉-头颈外科首都医科大学附属北京同仁医院首都医科大学附属同仁医院[2]Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing, People’s Republic of China研究所耳鼻咽喉科研究所首都医科大学附属北京同仁医院首都医科大学附属同仁医院
Purpose of reviewAllergic rhinitis is a highly prevalent inflammatory disease affecting 20-40% of the children worldwide. Allergen-specific immunotherapy (SIT) is an effective treatment for allergic rhinitis. This article reviews the recent advances in SIT for children.Recent findingsIn current clinical practice, immunotherapy is delivered as either subcutaneous immunotherapy or sublingual immunotherapy (SLIT). Most meta-analyses and reviews concluded a trend that subcutaneous immunotherapy was better than SLIT in reducing symptoms of allergic rhinitis and rescue medication use, however, SLIT has a better safety profile than subcutaneous immunotherapy. Additionally, the absence of pain on administration of therapy is a character of SLIT, which is well suited for children. T regulatory cells, especially Tr1 cells that secrete interleukin-10 and induce production of immunoglobulin G4, play a role during SIT.SummaryAlthough there is substantial evidence for effectiveness of both subcutaneous immunotherapy and SLIT, safer and more effective SIT approaches are needed. New approaches to improve SIT include omalizumab pretreatment, use of recombinant allergens, and alternate routes of administration.
基金:
Program for Changjiang Scholars and Innovative Research TeamProgram for Changjiang Scholars & Innovative Research Team in University (PCSIRT) [IRT13082]; National Science Fund for Distinguished Young ScholarsNational Natural Science Foundation of China (NSFC)National Science Fund for Distinguished Young Scholars [81025007]; Beijing Natural Science FoundationBeijing Natural Science Foundation [7131006]; Ministry of Health Foundation [201202005]; Capital Health Research and Development of Special [2011-1017-06]; Special Fund of Sanitation Elite Reconstruction of Beijing [2009-2-007]; Beijing Health Bureau Program [2011-3-043]
第一作者机构:[1]Department of Otolaryngology, Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University
通讯作者:
通讯机构:[1]Department of Otolaryngology, Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University[2]Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing, People’s Republic of China[*1]Beijing Institute of Otolaryngology, No. 17, HouGouHuTong, DongCheng District, Beijing 100005, People’s Republic of China
推荐引用方式(GB/T 7714):
Wang Chengshuo,Zhang Luo.Specific immunotherapy for allergic rhinitis in children[J].CURRENT OPINION IN OTOLARYNGOLOGY & HEAD AND NECK SURGERY.2014,22(6):487-494.doi:10.1097/MOO.0000000000000101.
APA:
Wang, Chengshuo&Zhang, Luo.(2014).Specific immunotherapy for allergic rhinitis in children.CURRENT OPINION IN OTOLARYNGOLOGY & HEAD AND NECK SURGERY,22,(6)
MLA:
Wang, Chengshuo,et al."Specific immunotherapy for allergic rhinitis in children".CURRENT OPINION IN OTOLARYNGOLOGY & HEAD AND NECK SURGERY 22..6(2014):487-494