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Specific immunotherapy for allergic rhinitis in children

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机构: [1]Department of Otolaryngology, Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University [2]Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing, People’s Republic of China
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关键词: allergic rhinitis children allergen immune tolerance specific immunotherapy T regulatory cells

摘要:
Purpose of reviewAllergic rhinitis is a highly prevalent inflammatory disease affecting 20-40% of the children worldwide. Allergen-specific immunotherapy (SIT) is an effective treatment for allergic rhinitis. This article reviews the recent advances in SIT for children.Recent findingsIn current clinical practice, immunotherapy is delivered as either subcutaneous immunotherapy or sublingual immunotherapy (SLIT). Most meta-analyses and reviews concluded a trend that subcutaneous immunotherapy was better than SLIT in reducing symptoms of allergic rhinitis and rescue medication use, however, SLIT has a better safety profile than subcutaneous immunotherapy. Additionally, the absence of pain on administration of therapy is a character of SLIT, which is well suited for children. T regulatory cells, especially Tr1 cells that secrete interleukin-10 and induce production of immunoglobulin G4, play a role during SIT.SummaryAlthough there is substantial evidence for effectiveness of both subcutaneous immunotherapy and SLIT, safer and more effective SIT approaches are needed. New approaches to improve SIT include omalizumab pretreatment, use of recombinant allergens, and alternate routes of administration.

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出版当年[2013]版:
大类 | 4 区 医学
小类 | 2 区 耳鼻喉科学
最新[2025]版
大类 | 3 区 医学
小类 | 3 区 耳鼻喉科学
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出版当年[2012]版:
Q2 OTORHINOLARYNGOLOGY
最新[2023]版:
Q2 OTORHINOLARYNGOLOGY

影响因子: 最新[2023版] 最新五年平均 出版当年[2012版] 出版当年五年平均 出版前一年[2011版] 出版后一年[2013版]

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第一作者机构: [1]Department of Otolaryngology, Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University
通讯作者:
通讯机构: [1]Department of Otolaryngology, Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University [2]Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing, People’s Republic of China [*1]Beijing Institute of Otolaryngology, No. 17, HouGouHuTong, DongCheng District, Beijing 100005, People’s Republic of China
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