Allergen-specific IL-10-secreting type I T regulatory cells, but not CD4(+)CD25(+)Foxp3(+) T cells, are decreased in peripheral blood of patients with persistent allergic rhinitis
We investigate the frequencies of CD4(+)CD25(+)Foxp3(+) T cells and allergen-specific IL-10(+)IL-4(-), IFN-gamma+IL-4(-), IL-4(+)IFN-gamma(-)CD4(+) T cells (which display characteristics of nTreg, Tr1-, Th1- and Th2- cells, respectively) in peripheral blood mononuclear cells (PBMCs) of patients with AR and of healthy individuals. In addition, we estimated the suppressive effect of CD4(+)CD25(+) Treg cells and allergen-specific, IL-10-secreting cells from both two groups. The frequency of CD4(+)CD25(+)Foxp3(+) T cells is similar in 43 AR patients compared with 38 healthy subjects. CD4(+)CD25(high) cells retain suppressive activity on allergen-stimulated cell proliferation and cytokine production of Th1 but not Th2 cells in both groups. However, the frequency of allergen-specific IL-10(+)IL-4(-)CD4(+) T cells is reduced in AR patients, and correlates inversely to clinical symptom scores. Allergen-specific, IL-10-secreting cells potently suppressed D. pteronyssinus major allergen 1-stimulated cell proliferation and cytokine production (IFN-gamma and IL-4) in healthy individuals. Altogether our data indicate that the number and function of CD4(+)CD25(+) Treg cells from allergic patients are not impaired. However, the deficiency of allergen-specific Tr1 cells may play a role in the development of AR. (C) 2010 Elsevier Inc. All rights reserved.
基金：
Ministry of Science and Technology of ChinaMinistry of Science and Technology, China [2007BAI18B15]; Beijing Science and Technology Program [Z0005190041531]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [30872846]; Beijing Natural Science FoundationBeijing Natural Science Foundation [7072017]
第一作者机构：[1]Beijing Inst Otolaryngol, Minist Educ, Key Lab Otolaryngol Head & Neck Surg, Beijing 100005, Peoples R China[2]Capital Med Univ, Beijing TongRen Hosp, Dept Otolaryngol Head & Neck Surg, Beijing 100730, Peoples R China
共同第一作者：
通讯作者：
通讯机构：[1]Beijing Inst Otolaryngol, Minist Educ, Key Lab Otolaryngol Head & Neck Surg, Beijing 100005, Peoples R China[2]Capital Med Univ, Beijing TongRen Hosp, Dept Otolaryngol Head & Neck Surg, Beijing 100730, Peoples R China[*1]Beijing Inst Otolaryngol, Minist Educ, Key Lab Otolaryngol Head & Neck Surg, 17 HouGouHuTong, Beijing 100005, Peoples R China
推荐引用方式(GB/T 7714)：
Han Demin,Wang Chengshuo,Lou Wei,et al.Allergen-specific IL-10-secreting type I T regulatory cells, but not CD4(+)CD25(+)Foxp3(+) T cells, are decreased in peripheral blood of patients with persistent allergic rhinitis[J].CLINICAL IMMUNOLOGY.2010,136(2):292-301.doi:10.1016/j.clim.2010.03.006.
APA：
Han, Demin,Wang, Chengshuo,Lou, Wei,Gu, Yili,Wang, Yang&Zhang, Luo.(2010).Allergen-specific IL-10-secreting type I T regulatory cells, but not CD4(+)CD25(+)Foxp3(+) T cells, are decreased in peripheral blood of patients with persistent allergic rhinitis.CLINICAL IMMUNOLOGY,136,(2)
MLA：
Han, Demin,et al."Allergen-specific IL-10-secreting type I T regulatory cells, but not CD4(+)CD25(+)Foxp3(+) T cells, are decreased in peripheral blood of patients with persistent allergic rhinitis".CLINICAL IMMUNOLOGY 136..2(2010):292-301
