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Decreased expression of EBI3 and Foxp3 in CD4+CD25+ regulatory T cells in murine experimental allergic rhinitis.

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资源类型：
Pubmed体系：
作者：
Ouyang Yuhui[1] * ; Nakao Atsuhito[3] ; Fan Erzhong[1] ; Li Ying[1] ; Zhao Liping[1] ; Zhang Wei[1] ; Han Demin[1,2] ; Zhang Luo[1,2] ;
机构： [1]Key Laboratory of Otolaryngology, Head and Neck Surgery (Ministry of Education), Beijing Institute of Otolaryngology [2]Department of Otolaryngology, Head and Neck Surgery, Beijing Tong Ren Hospital, Capital Medical University, Beijing , China [3]Department of Immunology, University of Yamanashi Faculty of Medicine, Yamanashi , Japan
出处：
DOI： 10.1159/000331928
ISSN：

关键词： Allergic rhinitis Epstein-Barr virus-induced gene 3 Forkhead transcription factor 3 Regulatory T cells Mouse

摘要：
Epstein-Barr virus-induced gene 3 (EBI3) is a widely expressed interleukin-12-related protein that plays a critical role in the regulation of effector T cells and inflammatory responses.Allergic rhinitis (AR) was induced in mice by both intraperitoneal injection and intranasal administration of ovalbumin. By using immunohistochemical techniques, we investigated EBI3 expression in mouse spleens. The expressions of EBI3 and forkhead transcription factor 3 (Foxp3) in CD4+CD25+ regulatory T (T(reg)) cells isolated from spleens were assessed by flow cytometry. RNA extraction and RT-PCR were used to measure EBI3 and Foxp3 mRNA expression.EBI3 and Foxp3 were expressed mainly in the white pulp of the spleens. Flow cytometry analysis showed that EBI3 and Foxp3 coexpressed in mouse CD4+CD25+ T(reg) cells. Furthermore, RT-PCR and flow cytometry analysis showed that expression of both Foxp3 and EBI3 was reduced in CD4+CD25+ T(reg) cells in an AR mouse model compared with controls, but there was no difference in the frequency of CD4+CD25+ T(reg) cells.The deficiency in CD4+CD25+ T(reg) cell suppressive activity in AR is associated with the molecular mediators EBI3 and Foxp3.Copyright © 2011 S. Karger AG, Basel.

基金：
National Science Fund for Distinguished Young Scholars (81025007), National Natural Science Foundation of China (30872846 and 30973282), Beijing Science and Technology Program (KZ200910025008), Beijing Natural Science Foundation (7102030) and the Special Fund of Sanitation Elite Reconstruction of Beijing (2009-2-007)
语种：
外文
PubmedID：
中科院(CAS)分区：
出版当年[2010]版：
大类 | 4 区 医学
小类 | 4 区 耳鼻喉科学
最新[2023]版：
大类 | 4 区 医学
小类 | 4 区 耳鼻喉科学
第一作者：
第一作者机构： [1]Key Laboratory of Otolaryngology, Head and Neck Surgery (Ministry of Education), Beijing Institute of Otolaryngology
通讯作者：
通讯机构： [1]Key Laboratory of Otolaryngology, Head and Neck Surgery (Ministry of Education), Beijing Institute of Otolaryngology [2]Department of Otolaryngology, Head and Neck Surgery, Beijing Tong Ren Hospital, Capital Medical University, Beijing , China
推荐引用方式(GB/T 7714)：
Ouyang Yuhui,Nakao Atsuhito,Fan Erzhong,et al.Decreased expression of EBI3 and Foxp3 in CD4+CD25+ regulatory T cells in murine experimental allergic rhinitis.[J].ORL; Journal For Oto-Rhino-Laryngology And Its Related Specialties.2011,73(6):313-20.doi:10.1159/000331928.
APA：
Ouyang Yuhui,Nakao Atsuhito,Fan Erzhong,Li Ying,Zhao Liping...&Zhang Luo.(2011).Decreased expression of EBI3 and Foxp3 in CD4+CD25+ regulatory T cells in murine experimental allergic rhinitis..ORL; Journal For Oto-Rhino-Laryngology And Its Related Specialties,73,(6)
MLA：
Ouyang Yuhui,et al."Decreased expression of EBI3 and Foxp3 in CD4+CD25+ regulatory T cells in murine experimental allergic rhinitis.".ORL; Journal For Oto-Rhino-Laryngology And Its Related Specialties 73..6(2011):313-20

相关文献

[1]Decreased Expression of EBI3 and Foxp3 in CD4+CD25+ Regulatory T Cells in Murine Experimental Allergic Rhinitis [2]Upregulation of Interleukin-35 Subunits in Regulatory T Cells in a Murine Model of Allergic Rhinitis [3]Expression of the Foxp3 Gene in Spleen Mononuclear Cells of a Mouse Model with Allergic Rhinitis [4]Expression of the Foxp3 gene in spleen mononuclear cells of a mouse model with allergic rhinitis. [5]Some polymorphisms in Epstein-Barr virus-induced gene 3 modify the risk for chronic rhinosinusitis [6]eb病毒诱导基因3蛋白的生物学效应 [7]FOXP3-marked IL-17a-producing regulatory T cells are increased in patients with allergic rhinitis [8]Allergen-specific IL-10-secreting type I T regulatory cells, but not CD4(+)CD25(+)Foxp3(+) T cells, are decreased in peripheral blood of patients with persistent allergic rhinitis [9]Specific immunotherapy for allergic rhinitis in children [10]Responses of Cd4(+) Cd25(+) Foxp3(+) and Il-10-Secreting Type I T Regulatory Cells to Cluster-Specific Immunotherapy for Allergic Rhinitis in Children.

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