机构：[1]Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, P.R. China临床科室耳鼻咽喉-头颈外科首都医科大学附属北京同仁医院首都医科大学附属同仁医院[2]Key Laboratory of Otolaryngology Head and Neck Surgery of Ministry of Education, Beijing, P.R. China首都医科大学附属同仁医院
Epigenetic regulation is an important player in the tumorigenesis, progression, and prognosis of various tumors, but its role in sinonasal squamous cell carcinomas has not been well addressed. The objective of this study was to investigate the genome-wide DNA methylation in the sinonasal squamous cell carcinoma tissues. DNA methylation in CpG islands and promoters was investigated in 7 sinonasal squamous cell carcinomas and paired normal mucosa tissues using a DNA Methylation CpG Island Plus Promoter Array. A total of 12207 differentially methylated sites were observed between tumor tissues and normal mucosa tissues. Sixteen sites containing 9 genes were significantly different at P<0.01. Of the 9 genes, 3 genes (PTPRN2, NLRP8, and GRIN3B) were hypomethylated and 6 genes (TACC2, LOC404266, RASL10A, HOXD9, OPCML, CNPY1) were hypermethylated in the sinonasal squamous cell carcinomas compared to the paired normal mucosa tissues. The categorizations, the gene network, and the protein interaction network of these 9 aberrantly methylated genes were further analyzed. This study was the first to investigate global DNA methylation in sinonasal squamous cell carcinomas. The identified genes might be hopeful to serve as diagnostic, prognostic, and predictive biomarkers in sinonasal squamous cell carcinomas.
基金：
National Natural Science Foundation of China (NSFC) [81670946]; Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support [XMLX201507]; Beijing Key Laboratory of Nasal Diseases, Capital Development Fund for medical research [2011-2005-06]; priming scientific research foundation for the senior researcher in Beijing Tongren Hospital, Capital Medical University [2016-YJJ-GGL-001, CFH2018-1-2052]
第一作者机构：[1]Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, P.R. China[2]Key Laboratory of Otolaryngology Head and Neck Surgery of Ministry of Education, Beijing, P.R. China
通讯作者：
通讯机构：[1]Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, P.R. China[2]Key Laboratory of Otolaryngology Head and Neck Surgery of Ministry of Education, Beijing, P.R. China[*1]Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Dong Jiao Min Xiang Street, Dongcheng District, Beijing 100730, P.R. China.
推荐引用方式(GB/T 7714)：
Yang Zheng,Zhang Yang,Xu Hongbo,et al.Genome-wide comparison of DNA methylation between sinonasal squamous cell carcinomas and paired normal mucosa tissues[J].INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE.2018,11(9):9493-9501.
APA：
Yang, Zheng,Zhang, Yang,Xu, Hongbo,Huang, Junwei,Guo, Wei&Huang, Zhigang.(2018).Genome-wide comparison of DNA methylation between sinonasal squamous cell carcinomas and paired normal mucosa tissues.INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE,11,(9)
MLA：
Yang, Zheng,et al."Genome-wide comparison of DNA methylation between sinonasal squamous cell carcinomas and paired normal mucosa tissues".INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE 11..9(2018):9493-9501
