机构：[1]College of Life Science and Bio-engineering, Beijing Molecular HydrogenResearch Center, Beijing University of Technology, Beijing 100124, People’sRepublic of China[2]Beijing Tongren Hospital, Capital Medical University,Beijing 100730, People’s Republic of China首都医科大学附属北京同仁医院首都医科大学附属同仁医院[3]Beijing Ophthalmology & VisionScience Key Lab, Beijing Tongren Eye Center, Beijing 100730, People’sRepublic of China首都医科大学附属北京同仁医院首都医科大学附属同仁医院[4]Department of Plastic Surgery, Peking Union MedicalCollege Hospital, Beijing 100730, People’s Republic of China[5]Beijing DitanHospital, Capital Medical University, Beijing 100015, People’s Republic ofChina
BackgroundBenign Lymphoepithelial Lesion (BLEL) is a rare disease observed in the adult population. Despite the growing numbers of people suffering from BLEL, the etiology and mechanisms underlying its pathogenesis remain unknown.MethodsIn the present study, we used gene and cytokines expression profiling, western blot and immunohistochemistry to get further insight into the cellular and molecular mechanisms involved in the pathogenesis of BLEL of the lacrimal gland.ResultsThe results showed that Macrophage Migration Inhibitory Factor (MIF) was the most highly expressed cytokine in BLEL, and its expression positively correlated with the expression of Th2 and Th17 cells cytokines. MIF was found to regulate biological functions and pathways involved in BLEL pathogenesis, such as proliferation, resistance to apoptosis, MAPK and PI3K/Akt pathways. We also found that MIF promotes fibrosis in BLEL by inducing BLEL fibroblast differentiation into myofibroblasts as well as the synthesis and the deposit of extracellular matrix in BLEL tissues.ConclusionsOur findings demonstrate the contribution of MIF to the pathogenesis of BLEL of the lacrimal gland and suggested MIF as a promising therapeutic target for its treatment.
基金：
National Natural Science Foundation of
China (81602408, 81371052) and 2018 Ri Xin Ren Cai project of Beijing
University of Technology (015000514118003).
第一作者机构：[1]College of Life Science and Bio-engineering, Beijing Molecular HydrogenResearch Center, Beijing University of Technology, Beijing 100124, People’sRepublic of China
共同第一作者：
通讯作者：
推荐引用方式(GB/T 7714)：
Adzavon Yao Mawulikplimi,Zhao Pengxiang,Ma Jianmin,et al.Macrophage migration inhibitory factor contributes to the pathogenesis of benign lymphoepithelial lesion of the lacrimal gland[J].CELL COMMUNICATION AND SIGNALING.2018,16:doi:10.1186/s12964-018-0284-4.
APA：
Adzavon, Yao Mawulikplimi,Zhao, Pengxiang,Ma, Jianmin,Zhang, Xujuan,Zhang, Xin...&Ma, Xuemei.(2018).Macrophage migration inhibitory factor contributes to the pathogenesis of benign lymphoepithelial lesion of the lacrimal gland.CELL COMMUNICATION AND SIGNALING,16,
MLA：
Adzavon, Yao Mawulikplimi,et al."Macrophage migration inhibitory factor contributes to the pathogenesis of benign lymphoepithelial lesion of the lacrimal gland".CELL COMMUNICATION AND SIGNALING 16.(2018)
