Association of intraocular pressure-related factors and retinal vessel diameter with optic disc rim area in subjects with and without primary open angle glaucoma
机构：[1]Capital Medical University, Ophthalmology and Visual Science Key Lab, Beijing首都医科大学附属同仁医院[2]School of Psychological and Cognitive Sciences, Peking University, Beijing,[3]Department of Ophthalmology, Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai,[4]School of Ophthalmology & Optometry, Wenzhou Medical College, Zhe Jiang, China[5]Queensland Eye Institute, Brisbane, Australia[6]University of Queensland, Brisbane, Australia
ImportanceThe data may support the notion that the intra-ocular pressure (IOP)-related factors and vascular factors were implicated concurrently in glaucomatous optic nerve damage. BackgroundTo study the association of intraocular pressure (IOP)-related factors, IOP, trans-lamina cribrosa pressure difference (TLCPD), cerebrospinal fluid pressure (CSFP) and retinal vessel diameters (RVD), central retinal arteriolar equivalent (CRAE), central retinal venular equivalent (CRVE) with neuro-retinal rim area (RA). DesignA population-based, cross-sectional study. ParticipantsA total of 6830 people aged 30years and over. MethodsAll participants underwent a comprehensive eye examination, fundus photograph-based measurements of RVD and Heidelberg retinal tomogram (HRT) measurement of optic disc. Main Outcome MeasuresRA, CRAE, CRVE, IOP, body mass index (BMI), CSFP and TLCPD. ResultsPrimary open-angle glaucoma (POAG) was diagnosed using two separate methods: 67 from expert consensus, and 125 from the International Society of Geographical and Epidemiologic Ophthalmology (ISGEO) classification. After excluding of those with high myopia or without gradable HRT images, 4194 non-glaucoma and 40 POAG were analysed for determinants of RA. On multivariable analysis determinants of reduced RA were POAG (P<0.001), higher IOP (P=0.03), higher refractive error (P<0.01), longer axial length (P=0.01), CRVE (P<0.001), lower BMI (P=0.015), older age (P<0.001) smaller disc area (P<0.001) and higher TLCPD (P=0.03). When age and/or BMI were omitted from the model, reduced RA was also associated with lower CSFP (P<0.001). Conclusions and RelevanceReduced RA is associated with narrow CRVE and higher IOP or lower CSFP. The data supports the concurrent role of IOP-related and vascular factors in glaucomatous optic nerve damage.
基金：
This study was supported by a grant from the Special Research. Fund of Ministry of Health of the People’s Republic of
China (No.201002019)
第一作者机构：[1]Capital Medical University, Ophthalmology and Visual Science Key Lab, Beijing
通讯作者：
通讯机构：[1]Capital Medical University, Ophthalmology and Visual Science Key Lab, Beijing[*1]Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, 1 Dongjiaominxiang Street, Dongcheng District, Beijing 100730, China.
推荐引用方式(GB/T 7714)：
Zhang Qing,Jan Catherine,Guo Chun Y.,et al.Association of intraocular pressure-related factors and retinal vessel diameter with optic disc rim area in subjects with and without primary open angle glaucoma[J].CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY.2018,46(4):389-399.doi:10.1111/ceo.13042.
APA：
Zhang, Qing,Jan, Catherine,Guo, Chun Y.,Wang, Feng H.,Liang, Yuan B....&Wang, Ning L..(2018).Association of intraocular pressure-related factors and retinal vessel diameter with optic disc rim area in subjects with and without primary open angle glaucoma.CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY,46,(4)
MLA：
Zhang, Qing,et al."Association of intraocular pressure-related factors and retinal vessel diameter with optic disc rim area in subjects with and without primary open angle glaucoma".CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY 46..4(2018):389-399
