机构：[1]Department of Otolaryngology–Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China临床科室耳鼻咽喉-头颈外科首都医科大学附属北京同仁医院首都医科大学附属同仁医院[2]Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing, China研究所耳鼻咽喉科研究所首都医科大学附属北京同仁医院首都医科大学附属同仁医院[3]Department of Allergy, Beijing TongRen Hospital, Capital Medical University, Beijing, China临床科室变态反应科首都医科大学附属北京同仁医院首都医科大学附属同仁医院[4]Department of Otorhinolaryngology, Beijing DiTan Hospital, Capital Medical University, Beijing, China
Background: The role of nasal nitric oxide (NO) in the diagnosis of allergic rhinitis (AR) is controversial. The aim of this study was to identify factors that may affect levels of nasal NO in AR patients and evaluate the role of nasal NO in the diagnosis of AR. Methods: Seventy-five AR patients and 31 healthy controls were enrolled in this study. AR symptom scores were assessed using the visual analog scale. Eosinophil cationic protein (ECP) was detected by enzyme-linked immunoassay, nasal NO was measured using a chemiluminescence analyzer, and nasal airway resistance (NAR) was assessed by active anterior rhinomanometry. Results: Nasal obstruction score, ECP, and NAR were found to be independently associated with nasal NO. Nasal NO level in patients with nasal obstruction score < 7 (mild-to-moderate obstruction) was significantly increased compared with healthy subjects (282.1 +/- 122.6 vs 150.7 +/- 48.4 ppb; p < 0.001), and significantly decreased in patients with nasal obstruction score7 (severe obstruction) (97.2 +/- 52.2 vs 150.7 +/- 48.4 ppb; p < 0.001). Nasal NO and ECP in secretion were positively correlated in patients with mild-to-moderate nasal obstruction (r = 0.678), but not in patients with severe nasal obstruction (r = 0.077). In patients with NAR < 0.65 Pa/cm(3)/s, the correlation coefficient was highest between NO and ECP (r = 0.685). The areas under the receiver operating characteristic curve for nasal NO level were 0.878 and 0.939 in patients with nasal obstruction scores < 7 and NAR < 0.65Pa/cm(3)/s, respectively. Conclusion: Nasal patency affects nasal NO level significantly, and may reflect the severity of nasal inflammation in AR patients with mild-to-moderate nasal obstruction, but not in patients with severe nasal obstruction. (C) 2018 ARSAAOA, LLC.
基金：
National Key R&D Program of China grant [2016YFC20160905200]; Program for Changjiang Scholars and Innovative Research Team grantProgram for Changjiang Scholars & Innovative Research Team in University (PCSIRT) [IRT13082]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81420108009, 81400444, 81470678, 81630023]; Special Fund of Capital Health Development grant [2011-1017-06, 2011-1017-02]; Special Fund of Sanitation Elite Reconstruction of Beijing grant [2009-2-007]; Beijing Health Bureau Program for High Level Talents grant [2011-3-043]; Beijing Municipal Administration of Hospitals' Mission Plan grant [SML20150203]; Capital Citizenry Health program grant [z161100000116062]
第一作者机构：[1]Department of Otolaryngology–Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China[2]Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing, China[3]Department of Allergy, Beijing TongRen Hospital, Capital Medical University, Beijing, China[4]Department of Otorhinolaryngology, Beijing DiTan Hospital, Capital Medical University, Beijing, China
通讯作者：
通讯机构：[1]Department of Otolaryngology–Head and Neck Surgery, Beijing TongRen Hospital, Capital Medical University, Beijing, China[2]Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing, China[3]Department of Allergy, Beijing TongRen Hospital, Capital Medical University, Beijing, China[*1]Beijing Institute of Otolaryngology, No. 17, HouGouHuTong, DongCheng District, Beijing 100005, China
推荐引用方式(GB/T 7714)：
Hou Jing,Lou Hongfei,Wang Yang,et al.Nasal ventilation is an important factor in evaluating the diagnostic value of nasal nitric oxide in allergic rhinitis[J].INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY.2018,8(6):686-694.doi:10.1002/alr.22087.
APA：
Hou, Jing,Lou, Hongfei,Wang, Yang,He, Fei,Cao, Feifei...&Zhang, Luo.(2018).Nasal ventilation is an important factor in evaluating the diagnostic value of nasal nitric oxide in allergic rhinitis.INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY,8,(6)
MLA：
Hou, Jing,et al."Nasal ventilation is an important factor in evaluating the diagnostic value of nasal nitric oxide in allergic rhinitis".INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY 8..6(2018):686-694
