机构：[1]Nantong Institute of Liver Diseases, Nantong Third People’s Hospital, Nantong University, Nantong, Jiangsu Province, China[2]Department of Invasive Technology, Nantong Third People’s Hospital, Nantong University, Nantong, Jiangsu Province, China[3]Department of Liver and Gallbladder Surgery, Nantong Third People’s Hospital, Nantong University, Nantong, Jiangsu Province, China[4]Department of Pathology, Nantong Third People’s Hospital, Nantong University, Nantong, Jiangsu Province, China[5]Department of Gastroenterology, Tongren Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide. Tumor recurrence and metastasis are major factors that contribute to the poor outcome of patients with HCC. However, it is difficult to predict the prognosis of hepatocellular carcinoma. Trafficking Protein Particle Complex 4 (Trappc4), is associated with tumorigenesis. The present study aimed to detect Trappc4 expression in HCC and its association with clinicopathological patient data. More importantly, this study reveals the relationship between Trappc4 and the prognosis of hepatocellular carcinoma. A total of 148 HCC tissues were assessed for expression of Trappc4 mRNA and protein with (reverse transcription polymerase chain reaction) RT-PCR (n=36), Western blotting (n=4) and immunohistochemistry (n=148), respectively. The data show that Trappc4 mRNA and protein are expressed at low levels in HCC tissues compared to adjacent tissues. immunohistochemical analysis revealed that 148 cases of HCC showed different degrees of positive expression. Statistical analysis showed that expression of Trappc4 was associated with histological differentiation, TNM stage, and vascular invasion (P < 0.05), but did not correlate with the patient's age, gender, tumor size (P > 0.05). Most importantly, HCC patients with low expression of Trappc4 had shorter survival time compared to patients with high expression. Trappc4 might be involved in the pathogenesis of HCC and could be an important prognostic marker in HCC patients.
基金：
National Natural Science Foundation of China (NSFC) [81600449, 81400611]; Natural Science Foundation of Jiangsu ProvinceNatural Science Foundation of Jiangsu Province [BK2016-0420]; Nantong Science and Technology Bureau [MS22015105, YYZ16039]
第一作者机构：[2]Department of Invasive Technology, Nantong Third People’s Hospital, Nantong University, Nantong, Jiangsu Province, China
共同第一作者：
通讯作者：
通讯机构：[1]Nantong Institute of Liver Diseases, Nantong Third People’s Hospital, Nantong University, Nantong, Jiangsu Province, China[2]Department of Invasive Technology, Nantong Third People’s Hospital, Nantong University, Nantong, Jiangsu Province, China[*1]Nantong Institute of Liver Diseases, Nantong Third People’s Hospital, Nantong University, No. 60 Middle Qingnian Road, Nantong 226006, Jiangsu Province, China.[*2]Department of Invasive Techno-logy, Nantong Third People’s Hospital, Nantong University, No. 60 Middle Qingnian Road, Nantong 226006, Jiangsu Province, China.
推荐引用方式(GB/T 7714)：
Shen Jian-Dong,Cai Xin-Feng,Wei Jue,et al.Low expression of trafficking protein particle complex 4 predicts poor prognosis in hepatocellular carcinoma[J].INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY.2018,11(5):2691-2698.
APA：
Shen, Jian-Dong,Cai, Xin-Feng,Wei, Jue,Gu, Chun-Yan,Ju, Lin-Ling...&Qi, Long-Ju.(2018).Low expression of trafficking protein particle complex 4 predicts poor prognosis in hepatocellular carcinoma.INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY,11,(5)
MLA：
Shen, Jian-Dong,et al."Low expression of trafficking protein particle complex 4 predicts poor prognosis in hepatocellular carcinoma".INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY 11..5(2018):2691-2698
