机构：[1]School of Biomedical Engineering, Capital Medical University, Beijing 100069, China[2]Beijing Key Laboratory of Fundamental Research on Biomechanics in Clinical Application, Capital Medical University, Beijing 100069, China[3]Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China临床科室内分泌科首都医科大学附属北京同仁医院首都医科大学附属同仁医院
BACKGROUND AND OBJECTIVE: Muscle-invasive bladder cancers (MIBCs) are heterogeneous cancers and can be grouped into basal-like and luminal subtypes that are highly reminiscent of those found in breast cancer. Like basal-like breast cancers, basal-like MIBCs are associated with advanced stage and metastatic disease. However, the biological and clinical significance of molecular subtypes of MIBCs remain unclear. Therefore, we implemented a serious of bioinformatics methods to explore genetic similarities between bladder and breast cancers. METHODS AND RESULTS: In the current study, by the application of multiple levels data analysis including random forest analysis, PPI and transcription factor regulation network construction, Gene Ontology (GO) and KEGG pathway enrichment analysis, we explored the genetics commonness between MIBC and breast cancers from the molecular heterogeneity based on the disease subtypes. CONCLUSIONS: Our study identified some basal-related and luminal-related genes shared by two cancers. These studies can help shed light on the potential relationships between MIBC and breast cancer as a whole.
基金：
Beijing Natural Science FoundationBeijing Natural Science Foundation [7142015]; Special Subject of Capital General Medicine Research [17QK15]; Capital Medical University [16JL58, 17JL54]
基金编号：714201517QK1516JL58 17JL54
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2017]版：
大类|4 区医学
小类|4 区工程：生物医学4 区卫生保健与服务
最新[2023]版：
大类|4 区医学
小类|4 区工程：生物医学4 区卫生保健与服务
JCR分区：
出版当年[2016]版：
Q4HEALTH CARE SCIENCES & SERVICESQ4ENGINEERING, BIOMEDICAL
最新[2023]版：
Q3HEALTH CARE SCIENCES & SERVICESQ4ENGINEERING, BIOMEDICAL
第一作者机构：[1]School of Biomedical Engineering, Capital Medical University, Beijing 100069, China[2]Beijing Key Laboratory of Fundamental Research on Biomechanics in Clinical Application, Capital Medical University, Beijing 100069, China
通讯作者：
通讯机构：[1]School of Biomedical Engineering, Capital Medical University, Beijing 100069, China[2]Beijing Key Laboratory of Fundamental Research on Biomechanics in Clinical Application, Capital Medical University, Beijing 100069, China[*1]School of Biomedical Engineering, Capital Medical University, Beijing 100069, China.
推荐引用方式(GB/T 7714)：
Xu Wenbin,Xia Hong,Liu Wei,et al.Exploration of genetics commonness between bladder cancer and breast cancer based on a silcio analysis on disease subtypes[J].TECHNOLOGY AND HEALTH CARE.2018,26:S361-S377.doi:10.3233/THC-174699.
APA：
Xu, Wenbin,Xia, Hong,Liu, Wei,Zheng, Weiying&Hua, Lin.(2018).Exploration of genetics commonness between bladder cancer and breast cancer based on a silcio analysis on disease subtypes.TECHNOLOGY AND HEALTH CARE,26,
MLA：
Xu, Wenbin,et al."Exploration of genetics commonness between bladder cancer and breast cancer based on a silcio analysis on disease subtypes".TECHNOLOGY AND HEALTH CARE 26.(2018):S361-S377
